{"id":"W2139824204","doi":"10.1128/mcb.20.10.3482-3496.2000","title":"Enhanced Transformation by a Plasma Membrane-Associated Met Oncoprotein: Activation of a Phosphoinositide 3′-Kinase-Dependent Autocrine Loop Involving Hyaluronic Acid and CD44","year":2000,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Royal Victoria Hospital","funders":"","keywords":"Biology; Hyaluronic acid; Autocrine signalling; Phosphoinositide 3-kinase; CD44; Cell biology; Transformation (genetics); Kinase; Membrane; Cancer research; Molecular biology; Signal transduction; Biochemistry; Receptor; PI3K/AKT/mTOR pathway; Genetics; Gene; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008144559,0.0002835104,0.0001314387,0.0001504929,0.00008726443,0.0002211927,0.0001325571,0.0001717945,0.0008877986],"category_scores_gemma":[0.00007202299,0.0001102121,0.0002154825,0.00009782868,0.0001372538,0.0001366939,0.0002189931,0.0003884909,0.0002021358],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002395781,"about_ca_system_score_gemma":0.0001755794,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004974579,"about_ca_topic_score_gemma":0.0007858621,"domain_scores_codex":[0.999915,0.00001231671,0.000005498267,0.00001093682,0.00002544644,0.00003087694],"domain_scores_gemma":[0.9999238,0.00001577037,0.00001874684,0.00001228794,0.00000575476,0.00002367844],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003332913,0.0000146248,0.00005093911,0.000005856603,0.000001117161,0.00002617304,0.000005917823,0.00001823877,0.9994028,0.00006845643,0.000009557638,0.0003630448],"study_design_scores_gemma":[0.00001326716,0.0001640098,0.002047421,0.000001508687,0.000007147192,0.0002446434,0.00001202385,0.0008160941,0.9956295,0.00002752968,0.001035165,0.000001731923],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974021,0.0003678706,0.001300121,0.00003961553,0.000008309325,0.00001115314,0.00006334705,0.00005270811,0.0007549052],"genre_scores_gemma":[0.9974114,0.0001982978,0.0008275895,0.00001323683,0.000003509773,0.00001317622,0.0001700201,0.000008091904,0.001354631],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008877986,"threshold_uncertainty_score":0.00297004,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005749730315368143,"score_gpt":0.2124386018091055,"score_spread":0.2066888714937374,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}