{"id":"W2139824204","doi":"10.1128/mcb.20.10.3482-3496.2000","title":"Enhanced Transformation by a Plasma Membrane-Associated Met Oncoprotein: Activation of a Phosphoinositide 3′-Kinase-Dependent Autocrine Loop Involving Hyaluronic Acid and CD44","year":2000,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Royal Victoria Hospital","funders":"","keywords":"Biology; Hyaluronic acid; Autocrine signalling; Phosphoinositide 3-kinase; CD44; Cell biology; Transformation (genetics); Kinase; Membrane; Cancer research; Molecular biology; Signal transduction; Biochemistry; Receptor; PI3K/AKT/mTOR pathway; Genetics; Gene; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001683926,0.0001659819,0.0003595204,0.00007600874,0.00006018646,0.0000106212,0.00003568946,0.000159105,0.0002756206],"category_scores_gemma":[0.00006604235,0.0001496002,0.00005987529,0.0001258536,0.00008775363,0.00006306848,0.00001195041,0.0001269324,0.000005836132],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004258785,"about_ca_system_score_gemma":0.0000438571,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001459174,"about_ca_topic_score_gemma":0.00000374088,"domain_scores_codex":[0.9990089,0.0001080932,0.0002942029,0.0002513289,0.0001184097,0.0002190869],"domain_scores_gemma":[0.9995922,0.00003465952,0.00008906824,0.0001327641,0.00005546586,0.00009588493],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002570362,0.00009441349,0.0002143354,0.00008882437,0.0001161099,0.00000595814,0.0001939052,0.000005753556,0.9850274,0.000193893,0.00001171581,0.01379065],"study_design_scores_gemma":[0.003069643,0.000857356,0.0001766882,0.0000857628,0.0001296544,0.00001076839,0.00009042392,0.001149426,0.9939086,0.00011776,0.0002680024,0.0001358519],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939618,0.001845767,0.002235118,0.000174806,0.00002513942,0.0004080464,0.00001675795,0.00004437704,0.00128815],"genre_scores_gemma":[0.9986591,0.0002444457,0.0001444273,0.0002836539,0.000008891385,0.00003592461,0.0003222117,0.00001548937,0.0002858629],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01365479,"threshold_uncertainty_score":0.6100519,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005749730315368143,"score_gpt":0.2124386018091055,"score_spread":0.2066888714937374,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}