{"id":"W2139876108","doi":"10.1128/aac.00878-07","title":"Pharmacokinetics and Pharmacodynamics of Piperaquine in a Murine Malaria Model","year":2007,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Malaria Research and Control","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Bentley (Canada)","funders":"National Health and Medical Research Council; Medical Research Council","keywords":"Parasitemia; Pharmacokinetics; Dihydroartemisinin; Piperaquine; Plasmodium berghei; Pharmacodynamics; Pharmacology; Medicine; Malaria; Chemistry; Plasmodium falciparum; Artemisinin; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002338469,0.0003325852,0.0003292889,0.0001438105,0.0000784735,0.0002322799,0.000152589,0.0002527423,0.0004378721],"category_scores_gemma":[0.0002593305,0.0001563809,0.0001650113,0.0000909727,0.00016089,0.0002665137,0.00007995089,0.0006666112,0.0002051418],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002372798,"about_ca_system_score_gemma":0.0001857556,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002927969,"about_ca_topic_score_gemma":0.0004300085,"domain_scores_codex":[0.999884,0.00003591883,0.000006406152,0.00002324532,0.00003305636,0.00001741731],"domain_scores_gemma":[0.9998633,0.00002307743,0.00004992085,0.00001727118,0.00001480104,0.00003167992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002408385,0.0002486011,0.0009678027,0.00004364977,0.00001374625,0.00004044037,0.00002913303,0.000756248,0.9882401,0.00004556127,0.0001932173,0.007013009],"study_design_scores_gemma":[0.0004887261,0.03372494,0.02710353,0.00001935769,0.0001324244,0.0009666967,0.00004588569,0.01415586,0.9178177,0.0001807089,0.00531919,0.00004502076],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993501,0.001597791,0.003504951,0.00009641322,0.00001595374,0.00007589417,0.0003926592,0.0001344523,0.0006809285],"genre_scores_gemma":[0.9933028,0.001140356,0.003583832,0.00008997761,0.0000184562,0.0001234213,0.0006558102,0.00002678887,0.00105863],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004378721,"threshold_uncertainty_score":0.001721621,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01373634753750899,"score_gpt":0.3062993075268456,"score_spread":0.2925629599893367,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}