{"id":"W2139879310","doi":"10.1016/j.tips.2004.06.005","title":"How antipsychotics become anti-‘psychotic’ – from dopamine to salience to psychosis","year":2004,"lang":"en","type":"review","venue":"Trends in Pharmacological Sciences","topic":"Schizophrenia research and treatment","field":"Medicine","cited_by":156,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"","keywords":"Psychosis; Dopamine; Psychology; Salience (neuroscience); Dysphoria; Psychiatry; Dopamine hypothesis of schizophrenia; Attribution; Clinical psychology; Neuroscience; Dopamine receptor; Anxiety; Social psychology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0006436633,0.0007203156,0.00212323,0.001408,0.0002021892,0.0002607437,0.001258626,0.0002914244,0.001413518],"category_scores_gemma":[0.0001784318,0.0004341991,0.000483083,0.00601217,0.0004520642,0.0001438561,0.0002416512,0.0007275245,0.0004339325],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004953715,"about_ca_system_score_gemma":0.0003105439,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001007525,"about_ca_topic_score_gemma":0.0001372658,"domain_scores_codex":[0.9947797,0.0002288496,0.0007054411,0.001758536,0.001270098,0.001257396],"domain_scores_gemma":[0.9975153,0.00042065,0.0001772975,0.0004533475,0.00006333876,0.001370051],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004957999,0.001184077,0.0007468594,0.0003326156,0.0001430039,0.0005218066,0.00003168161,0.00001227661,0.00002793886,0.0001117056,0.001962343,0.9944299],"study_design_scores_gemma":[0.006096479,0.005970513,0.03040188,0.01226604,0.001539948,0.0001588517,0.00005800268,0.00002683398,0.0001092007,0.0006581466,0.9410943,0.001619828],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01958116,0.9638335,0.00005226329,0.01151006,0.00145219,0.002006333,0.0002512957,0.0001634861,0.001149755],"genre_scores_gemma":[0.0227613,0.9611714,0.01362306,0.0008197126,0.000439116,0.0004443672,0.00007829149,0.00003496819,0.0006277437],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9928101,"threshold_uncertainty_score":0.999811,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1850291593961038,"score_gpt":0.4851639066129809,"score_spread":0.3001347472168771,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}