{"id":"W2139899944","doi":"10.1093/hmg/10.23.2727","title":"Regulation of murine survival motor neuron (Smn) protein levels by modifying Smn exon 7 splicing","year":2001,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Neurogenetic and Muscular Disorders Research","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"National Institute of Neurological Disorders and Stroke","keywords":"SMN1; Exon; Biology; Minigene; Spinal muscular atrophy; Molecular biology; Exon trapping; Tandem exon duplication; Alternative splicing; Genetics; Exonic splicing enhancer; RNA splicing; Gene; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001601582,0.0003281623,0.0001086648,0.0001857985,0.00009260992,0.0001775845,0.0001486369,0.0002073939,0.0004688733],"category_scores_gemma":[0.0001383211,0.0001295935,0.0001803202,0.00005819223,0.0001894703,0.00009243338,0.0001435202,0.0002163703,0.0002891683],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002916483,"about_ca_system_score_gemma":0.00009079547,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002011614,"about_ca_topic_score_gemma":0.0004564118,"domain_scores_codex":[0.9998446,0.00003451365,0.00001978464,0.00004366822,0.00003115801,0.00002636711],"domain_scores_gemma":[0.9998177,0.00004042904,0.00007086469,0.00001664663,0.00001813925,0.0000361989],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004383012,0.000009896642,0.0001718043,0.00000952996,0.000001824497,0.00001915227,0.000008798782,0.00003280681,0.9992531,0.00004828225,0.000008890908,0.000392033],"study_design_scores_gemma":[0.00001157352,0.0002697369,0.003498349,0.000005824852,0.00001132997,0.0001335459,0.00001117375,0.0006727989,0.993993,0.00003810071,0.001350992,0.000003603409],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979672,0.0003722449,0.0009826482,0.00002357286,0.00001386445,0.000009995056,0.0001408746,0.00003735661,0.0004522055],"genre_scores_gemma":[0.9944592,0.0003730336,0.003024653,0.00003287544,0.000008368072,0.00003162204,0.0006152963,0.00003202889,0.001422889],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004688733,"threshold_uncertainty_score":0.002116024,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04733564715715026,"score_gpt":0.3178364320050903,"score_spread":0.27050078484794,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}