{"id":"W2139910608","doi":"10.1128/aac.47.11.3644-3646.2003","title":"Favorable Interactions between Enfuvirtide and 1-β- <scp>d</scp> -2,6-Diaminopurine Dioxolane In Vitro","year":2003,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Enfuvirtide; In vitro; Protease; Reverse transcriptase; Chemistry; Dioxolane; Virology; Human immunodeficiency virus (HIV); Didanosine; Biology; Pharmacology; Enzyme; Biochemistry; Antiretroviral therapy; Immunology; RNA; Viral load; Antigen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003178192,0.0005143135,0.0006201303,0.0002612708,0.0002548193,0.0003965332,0.0002798759,0.0003256236,0.001494341],"category_scores_gemma":[0.0005661786,0.0002665788,0.0003018801,0.0001690688,0.0001705902,0.0002719549,0.0002636166,0.0002811275,0.0003245655],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001988374,"about_ca_system_score_gemma":0.0002163074,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008928916,"about_ca_topic_score_gemma":0.001313856,"domain_scores_codex":[0.9994596,0.0002358884,0.00002912223,0.00005562898,0.000127418,0.00009253436],"domain_scores_gemma":[0.9996661,0.0001644384,0.00006666378,0.00001056107,0.00003698005,0.00005529922],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001649969,0.0002349731,0.001385278,0.0002654858,0.00007802605,0.0002712964,0.00004132121,0.0008785296,0.9883201,0.0001010932,0.0001892695,0.006584625],"study_design_scores_gemma":[0.0001700267,0.007255567,0.005559372,0.00002055015,0.0001292917,0.001135644,0.00005537365,0.001618325,0.978465,0.00005849872,0.005509994,0.00002236564],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882311,0.008096267,0.0008909563,0.00009079697,0.00003929625,0.00005054287,0.0002369684,0.00002946296,0.002334563],"genre_scores_gemma":[0.9951459,0.002020154,0.001767937,0.00004056563,0.000033713,0.00001901342,0.000334252,0.000008147367,0.0006304109],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001494341,"threshold_uncertainty_score":0.004999101,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01397166576414162,"score_gpt":0.2573913026190984,"score_spread":0.2434196368549568,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}