{"id":"W2139926908","doi":"10.1177/1087057106298287","title":"Using Ligand-Induced Conformational Change to Screen for Compounds Targeting G-Protein-Coupled Receptors","year":2007,"lang":"en","type":"article","venue":"SLAS DISCOVERY","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"Canada Research Chairs","keywords":"G protein-coupled receptor; Receptor; Agonist; Ligand (biochemistry); Drug discovery; Inverse agonist; Chemistry; Biochemistry; Cell biology; Biology; Biophysics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000589697,0.0001823128,0.0001724278,0.00007692086,0.0001938755,0.00009023327,0.0001571531,0.0001505749,0.00002387488],"category_scores_gemma":[0.0000837761,0.0001774182,0.0001319582,0.0001026955,0.00001787395,0.0000329352,0.00008959848,0.00006897096,0.000007586087],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003863532,"about_ca_system_score_gemma":0.00006383465,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007876845,"about_ca_topic_score_gemma":0.00002885859,"domain_scores_codex":[0.9987988,0.00001548987,0.0003108544,0.0002913764,0.0001851262,0.0003983866],"domain_scores_gemma":[0.9994681,0.00001954534,0.0001182337,0.0001624727,0.0001165972,0.000115019],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001780565,0.00002067793,0.0001443447,0.00001716823,0.00003467207,5.589267e-7,0.0001066374,0.000049749,0.9977139,0.0009659631,0.0002677315,0.0005005281],"study_design_scores_gemma":[0.0005399273,0.000275371,0.0001039228,0.0000435497,0.00001223356,0.000002920065,0.0003315987,0.0008484126,0.9903552,0.0001481899,0.007050561,0.000288124],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8414653,0.00009636094,0.1570991,0.00004887676,0.0004384959,0.0005795235,0.00003340781,0.00001437206,0.000224604],"genre_scores_gemma":[0.9858623,0.000004807548,0.01189521,0.0004748445,0.001118243,0.00004210354,0.000357127,0.00003489997,0.0002105074],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1452038,"threshold_uncertainty_score":0.7234904,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04938049950569059,"score_gpt":0.303273219937241,"score_spread":0.2538927204315504,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}