{"id":"W2139926908","doi":"10.1177/1087057106298287","title":"Using Ligand-Induced Conformational Change to Screen for Compounds Targeting G-Protein-Coupled Receptors","year":2007,"lang":"en","type":"article","venue":"SLAS DISCOVERY","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"Canada Research Chairs","keywords":"G protein-coupled receptor; Receptor; Agonist; Ligand (biochemistry); Drug discovery; Inverse agonist; Chemistry; Biochemistry; Cell biology; Biology; Biophysics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002980585,0.0004517643,0.0004378778,0.000478567,0.0002804042,0.0003464529,0.0003113651,0.0004240454,0.001589414],"category_scores_gemma":[0.0003584821,0.0002291363,0.0004193454,0.0004211088,0.0002764864,0.0002461495,0.0002901216,0.0007294262,0.0003918195],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004713437,"about_ca_system_score_gemma":0.0003718422,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007249708,"about_ca_topic_score_gemma":0.001746853,"domain_scores_codex":[0.9998121,0.00003436083,0.000009492955,0.00002905326,0.00005659085,0.00005840132],"domain_scores_gemma":[0.9998707,0.00004019704,0.00002871455,0.00001576896,0.00002097878,0.00002365247],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002399769,0.0001451262,0.0002833401,0.00006843477,0.00002758778,0.0001130258,0.00001688233,0.001008548,0.9920455,0.0002769788,0.0001924412,0.005582206],"study_design_scores_gemma":[0.0002638979,0.002915259,0.00128925,0.000008405073,0.00005625257,0.0003113115,0.00002682108,0.002095193,0.9901083,0.000140456,0.0027615,0.00002332397],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9846319,0.001737129,0.008823195,0.0005054463,0.00009811391,0.000399175,0.00073824,0.0002468129,0.002820006],"genre_scores_gemma":[0.9891182,0.001328202,0.005317878,0.0003060297,0.00001584677,0.0001396545,0.0007455812,0.00002840424,0.003000266],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001589414,"threshold_uncertainty_score":0.005317152,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04938049950569059,"score_gpt":0.303273219937241,"score_spread":0.2538927204315504,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}