{"id":"W2139954007","doi":"10.1016/j.yjmcc.2009.04.011","title":"Rosiglitazone-induced heart remodelling is associated with enhanced turnover of myofibrillar protein and mTOR activation","year":2009,"lang":"en","type":"article","venue":"Journal of Molecular and Cellular Cardiology","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Rosiglitazone; Internal medicine; Endocrinology; Phospholamban; Protein turnover; Protein degradation; Chemistry; Muscle hypertrophy; Protein kinase B; PI3K/AKT/mTOR pathway; Diabetic cardiomyopathy; Phosphorylation; Biology; Signal transduction; Insulin; Biochemistry; Medicine; Heart failure; Cardiomyopathy; Protein biosynthesis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001637109,0.0003852549,0.0005059434,0.000406285,0.0002432792,0.0004648746,0.0002464271,0.0004660926,0.001783209],"category_scores_gemma":[0.0001775463,0.000330171,0.0005183843,0.0002510781,0.0002667883,0.0002114881,0.0002312362,0.001154686,0.0004193404],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002256744,"about_ca_system_score_gemma":0.0001689045,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003647865,"about_ca_topic_score_gemma":0.0008023113,"domain_scores_codex":[0.9998507,0.00001998714,0.00001617145,0.00002872323,0.00004010407,0.00004428313],"domain_scores_gemma":[0.9997484,0.00002804819,0.0001086368,0.00003405191,0.00001401957,0.00006670985],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00300285,0.0001042557,0.0007102302,0.00005789368,0.00003154876,0.0002704668,0.00001321157,0.00002161215,0.9938331,0.00005501609,0.00006464688,0.001835239],"study_design_scores_gemma":[0.0005971228,0.001370895,0.1351994,0.00002853669,0.0002009003,0.001497488,0.0001152222,0.0007036201,0.8578117,0.000202163,0.002249602,0.00002321083],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994431,0.003092125,0.001033647,0.0001885999,0.00009033963,0.00002615227,0.0002647307,0.0001061061,0.0007672049],"genre_scores_gemma":[0.9952615,0.001050971,0.0007517128,0.00009169022,0.00004824253,0.0000637901,0.0004857641,0.00002891212,0.002217362],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001783209,"threshold_uncertainty_score":0.005965471,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007611012202213186,"score_gpt":0.2155389992771049,"score_spread":0.2079279870748917,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}