{"id":"W2139966699","doi":"10.1158/1535-7163.mct-10-0677","title":"Notch Signaling Pathway as a Therapeutic Target in Breast Cancer","year":2010,"lang":"en","type":"review","venue":"Molecular Cancer Therapeutics","topic":"Developmental Biology and Gene Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":152,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Center for Research Resources; University of California, Davis; Cancer Research Coordinating Committee; Office of Research and Development; Purdue University","keywords":"Notch signaling pathway; Cancer; Breast cancer; Signal transduction; Cancer research; Medicine; Disease; Biology; Bioinformatics; Pharmacology; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0002612933,0.0006834406,0.00091933,0.0001632002,0.0000977979,0.00004247757,0.0005088499,0.001298778,0.0001647919],"category_scores_gemma":[0.000004119412,0.000599096,0.0004320746,0.000345,0.0001448118,0.000005554582,0.0001408022,0.0006561848,0.0000316883],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001340517,"about_ca_system_score_gemma":0.00118549,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006768169,"about_ca_topic_score_gemma":0.0001034945,"domain_scores_codex":[0.9974853,0.000265975,0.00059751,0.0008464654,0.0002307644,0.0005739731],"domain_scores_gemma":[0.9989026,0.00001829552,0.000326938,0.0005533088,0.00009762744,0.0001011942],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005100472,0.00007562876,0.0001985269,0.0006338883,0.0005332293,0.00002105206,0.00004077148,0.00003969641,0.114232,0.00005123229,0.00001757665,0.8841054],"study_design_scores_gemma":[0.0003684633,0.00005223437,0.00005276557,0.001092442,0.0002809344,0.00007855297,0.000009132379,0.000007655085,0.03050473,0.0001760326,0.966599,0.0007780858],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002502429,0.9951951,0.0002357817,0.0002154914,0.0006827615,0.0007268258,0.0002166246,0.00002365616,0.0002013133],"genre_scores_gemma":[0.005370378,0.9906407,0.0002407646,0.001627477,0.0003346452,0.0005791981,0.0006045846,0.0001473018,0.0004549761],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9665814,"threshold_uncertainty_score":0.9999977,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02217025574261026,"score_gpt":0.314756041743817,"score_spread":0.2925857860012067,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}