{"id":"W2139976232","doi":"10.1021/bp034237l","title":"High-Titer Adenovirus Vector Production in 293S Cell Perfusion Culture","year":2004,"lang":"en","type":"article","venue":"Biotechnology Progress","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Titer; Cell culture; Viral vector; Cell; Perfusion; Recombinant DNA; Biology; Chemistry; Adenoviridae; Molecular biology; Chromatography; Virology; Virus; Biochemistry; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001930818,0.0002117587,0.0001689288,0.0001904385,0.00009341088,0.00002045452,0.0003892225,0.000821004,0.00001983037],"category_scores_gemma":[0.00004206671,0.0001900179,0.00005791161,0.0003613235,0.0003408653,0.000006570353,0.0001982895,0.0003682288,0.00008654562],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007598733,"about_ca_system_score_gemma":0.0001021495,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002181091,"about_ca_topic_score_gemma":0.0002134245,"domain_scores_codex":[0.9984745,0.00005928729,0.0002004344,0.0006441244,0.0001744917,0.0004471702],"domain_scores_gemma":[0.9991973,0.000001644896,0.0000709606,0.0006048494,0.00007035454,0.0000548865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007285342,0.000278031,0.0008446699,0.00002207403,0.00001363714,0.00002273891,0.00006480134,0.00005839308,0.9875405,0.00006407144,0.0003181285,0.0100444],"study_design_scores_gemma":[0.001110055,0.002245761,0.0006366072,0.00001960705,0.000005578197,0.00002618499,0.00004986007,0.000002091263,0.9866324,0.0001561788,0.008893131,0.0002225527],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905534,0.004559341,0.00003244823,0.003953325,0.0002492915,0.0005151979,0.000008792586,0.00009104828,0.00003717332],"genre_scores_gemma":[0.9968851,0.0007690987,0.001327163,0.0001046683,0.0002449837,0.0001068539,0.00007583393,0.00003663783,0.0004496815],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009821851,"threshold_uncertainty_score":0.7748706,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00899902549234295,"score_gpt":0.2658318322297971,"score_spread":0.2568328067374542,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}