{"id":"W2139976232","doi":"10.1021/bp034237l","title":"High-Titer Adenovirus Vector Production in 293S Cell Perfusion Culture","year":2004,"lang":"en","type":"article","venue":"Biotechnology Progress","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Titer; Cell culture; Viral vector; Cell; Perfusion; Recombinant DNA; Biology; Chemistry; Adenoviridae; Molecular biology; Chromatography; Virology; Virus; Biochemistry; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001010264,0.0007595671,0.001068317,0.0004065807,0.0003932997,0.000791811,0.0007866413,0.0006520722,0.001627606],"category_scores_gemma":[0.0004428515,0.0004202414,0.0006774725,0.0005101006,0.0003794956,0.0004854237,0.0005674482,0.001777018,0.002585661],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004768821,"about_ca_system_score_gemma":0.0003700596,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009168906,"about_ca_topic_score_gemma":0.0007287498,"domain_scores_codex":[0.999353,0.0001249135,0.00008348424,0.0001600227,0.0002048729,0.0000736316],"domain_scores_gemma":[0.9996942,0.00007416692,0.00003781946,0.00007367261,0.00008353274,0.00003660495],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000624987,0.00003842436,0.0001508869,0.00005311125,0.000005224902,0.00004419998,0.00003917142,0.0001464724,0.9973911,0.0001955954,0.0001026519,0.001770514],"study_design_scores_gemma":[0.00002168965,0.0002419089,0.0006407852,0.00001197331,0.00002129867,0.0002170421,0.00002001136,0.00202585,0.9907957,0.0001029035,0.005885589,0.00001536442],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6187249,0.002288042,0.3592463,0.0001973333,0.0004431906,0.001715993,0.005980341,0.002157881,0.009246144],"genre_scores_gemma":[0.632787,0.003422927,0.3359086,0.0001663271,0.0001158137,0.001555883,0.01200822,0.0005690288,0.01346618],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001627606,"threshold_uncertainty_score":0.005444825,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00899902549234295,"score_gpt":0.2658318322297971,"score_spread":0.2568328067374542,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}