{"id":"W2139995836","doi":"10.1158/1535-7163.mct-07-2217","title":"Synergistic effects of methylnaltrexone with 5-fluorouracil and bevacizumab on inhibition of vascular endothelial growth factor–induced angiogenesis","year":2008,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Cancer Treatment and Pharmacology","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"","keywords":"Pharmacology; RHOA; Angiogenesis; Vascular endothelial growth factor; Chemistry; Naltrexone; Protein kinase B; Cancer research; Medicine; Receptor; Opioid; Signal transduction; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000188346,0.0003572254,0.0004084739,0.0002339417,0.00009368745,0.0002114762,0.0001550171,0.0002164522,0.0008400524],"category_scores_gemma":[0.0001494795,0.0001492402,0.0003545908,0.000113853,0.000136416,0.0001651168,0.0002057142,0.0004253965,0.000128919],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001853452,"about_ca_system_score_gemma":0.0002391126,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005931262,"about_ca_topic_score_gemma":0.002511093,"domain_scores_codex":[0.9998385,0.00004337,0.0000142778,0.00002175747,0.00003854007,0.00004355624],"domain_scores_gemma":[0.9999236,0.00002156997,0.00002046815,0.000006163983,0.000006656426,0.00002145571],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005893239,0.0001885819,0.0003145623,0.00008729959,0.00003041561,0.00008055734,0.00001770312,0.0003287634,0.9905511,0.0000863175,0.0001081762,0.007617079],"study_design_scores_gemma":[0.000232929,0.007749851,0.008678185,0.00002123422,0.0001357813,0.0006286846,0.0000450384,0.00367256,0.9752774,0.0000560123,0.003487441,0.00001487704],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904925,0.005106192,0.00142537,0.0001251804,0.00007211553,0.00009033512,0.0001004892,0.00004162704,0.002546098],"genre_scores_gemma":[0.9955186,0.001537529,0.001919043,0.00006408698,0.00002028158,0.00004108672,0.00009930918,0.000003456974,0.0007967053],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008400524,"threshold_uncertainty_score":0.00281018,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02684757203715815,"score_gpt":0.2854884292025764,"score_spread":0.2586408571654182,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}