{"id":"W2140019947","doi":"10.1523/jneurosci.4485-14.2015","title":"Microglia-Dependent Alteration of Glutamatergic Synaptic Transmission and Plasticity in the Hippocampus during Peripheral Inflammation","year":2015,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":225,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; Alberta Innovates; Fondation pour la Recherche Médicale; Crohn's and Colitis Foundation of Canada; Crohn's and Colitis Foundation","keywords":"Long-term potentiation; Neuroscience; AMPA receptor; Hippocampal formation; Synaptic plasticity; Neurotransmission; Hippocampus; Excitatory postsynaptic potential; Microglia; Glutamatergic; Glutamate receptor; Schaffer collateral; Biology; Inflammation; Medicine; Receptor; Immunology; Internal medicine; Inhibitory postsynaptic potential","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005040312,0.0001161869,0.0001609157,0.0002098955,0.0001168912,0.0001265988,0.0003073085,0.00003318062,0.000003717506],"category_scores_gemma":[0.0006240173,0.00008132575,0.00003906131,0.0003173595,0.0001070981,0.0007188301,0.00003187698,0.0002116514,0.000001106123],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003077711,"about_ca_system_score_gemma":0.00008015791,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001200503,"about_ca_topic_score_gemma":0.000001676596,"domain_scores_codex":[0.9979454,0.0004047065,0.0005960046,0.000209843,0.0006837504,0.0001602394],"domain_scores_gemma":[0.9991467,0.0001183188,0.0004386515,0.000105455,0.00008662247,0.0001042723],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009402194,0.00003863341,0.00009742664,0.00001938175,2.626268e-7,0.00008276013,0.001044038,0.005398097,0.9923058,0.0002643442,0.000003683827,0.0006515958],"study_design_scores_gemma":[0.0008094297,0.0003563534,0.003743103,0.00003489895,0.000005843135,0.001199874,0.00008320142,0.01666673,0.9762443,0.0007400244,0.00004022073,0.00007600704],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962333,0.0000158779,0.002488421,0.0007062908,0.0003589488,0.0001612113,0.000001537631,0.000009612422,0.00002478119],"genre_scores_gemma":[0.9994475,0.00006546943,0.0001555228,0.0002496389,0.00005503127,0.000002189936,9.465749e-8,0.000007145042,0.0000174538],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01606144,"threshold_uncertainty_score":0.3316368,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03381977762232923,"score_gpt":0.2613065423739055,"score_spread":0.2274867647515763,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}