{"id":"W2140023800","doi":"10.1002/cbic.201100415","title":"Tuning the Activity of Mitochondria‐Penetrating Peptides for Delivery or Disruption","year":2012,"lang":"en","type":"article","venue":"ChemBioChem","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Terry Fox Foundation","keywords":"Mitochondrion; Peptide; Chemistry; Mitochondrial membrane transport protein; Cytosol; Biophysics; Mitochondrial matrix; Inner mitochondrial membrane; Mitochondrial permeability transition pore; Cell biology; Biochemistry; Membrane; Cytochrome c; Biology; Apoptosis; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003201758,0.0003218741,0.0002053994,0.000102094,0.0001013691,0.0003146451,0.0001332028,0.000331556,0.0005305785],"category_scores_gemma":[0.0003389698,0.0001125707,0.0001258381,0.0001058288,0.0002806139,0.0003566813,0.0001632594,0.0004823283,0.0001589139],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001965909,"about_ca_system_score_gemma":0.0001429524,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001033876,"about_ca_topic_score_gemma":0.000203376,"domain_scores_codex":[0.9998343,0.00003722485,0.00002011937,0.00003430695,0.00004770967,0.00002632716],"domain_scores_gemma":[0.9997575,0.0001020622,0.00007555292,0.00001723663,0.00001953067,0.00002808728],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001809673,0.000006440752,0.00003447185,0.00001303886,0.000001292809,0.000008547644,0.000004406909,0.00004412041,0.9993788,0.0000243529,0.000003722214,0.0004626018],"study_design_scores_gemma":[0.000004829707,0.000150334,0.0004402966,0.000001668565,0.000004132395,0.00004080846,0.000004746972,0.0002914143,0.9987055,0.00001710218,0.0003370525,0.000002030827],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942615,0.001016748,0.003967283,0.00007260129,0.00001315723,0.00002808693,0.00005838977,0.0000251182,0.0005570879],"genre_scores_gemma":[0.9942548,0.0009374447,0.004179075,0.00006583602,0.000009452054,0.00002775878,0.00008171031,0.00001317002,0.0004306896],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005305785,"threshold_uncertainty_score":0.001774907,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03259502624358428,"score_gpt":0.2895696659039083,"score_spread":0.256974639660324,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}