{"id":"W2140023800","doi":"10.1002/cbic.201100415","title":"Tuning the Activity of Mitochondria‐Penetrating Peptides for Delivery or Disruption","year":2012,"lang":"en","type":"article","venue":"ChemBioChem","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Terry Fox Foundation","keywords":"Mitochondrion; Peptide; Chemistry; Mitochondrial membrane transport protein; Cytosol; Biophysics; Mitochondrial matrix; Inner mitochondrial membrane; Mitochondrial permeability transition pore; Cell biology; Biochemistry; Membrane; Cytochrome c; Biology; Apoptosis; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001804528,0.0001248683,0.0001151891,0.00001696244,0.00009060721,0.00001505434,0.0001779253,0.0001123724,0.00001428746],"category_scores_gemma":[0.0001387121,0.00008625328,0.0001185266,0.00005513401,0.00006923624,0.0000115592,0.00007933668,0.00006003127,0.000003889274],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001042347,"about_ca_system_score_gemma":0.00004232308,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000114088,"about_ca_topic_score_gemma":0.00001275856,"domain_scores_codex":[0.9993246,0.00002271413,0.0001512373,0.0001765508,0.00008048007,0.0002444148],"domain_scores_gemma":[0.9994237,0.00004470579,0.0001127668,0.000274236,0.00009426383,0.00005029654],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002003431,0.00005501997,0.001408037,0.00003645909,0.00004373808,9.183294e-8,0.0001237539,0.000003127659,0.9910693,0.00001697433,0.00146314,0.005580031],"study_design_scores_gemma":[0.0002524044,0.0001666288,0.001717963,0.00002305168,0.00002675293,0.000006774841,0.0003212823,0.00006250421,0.9946493,0.000007610444,0.002642257,0.0001234532],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956344,0.0006207539,0.002773489,0.00005264646,0.0001818575,0.0002015916,0.00001542626,0.000007386954,0.0005123824],"genre_scores_gemma":[0.9974827,0.0000774065,0.0008093041,0.00009112379,0.0005237637,0.00005305507,0.00004795001,0.00001569916,0.0008990191],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005456578,"threshold_uncertainty_score":0.3517307,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03259502624358428,"score_gpt":0.2895696659039083,"score_spread":0.256974639660324,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}