{"id":"W2140054283","doi":"10.1073/pnas.1107032108","title":"Structural basis for the sequence-specific recognition of human ISG15 by the NS1 protein of influenza B virus","year":2011,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Institutes of Health; Howard Hughes Medical Institute","keywords":"ISG15; Linker; Chemistry; Interferon-stimulated gene; Binding site; Binding domain; Peptide sequence; Biology; Ubiquitin; Biochemistry; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006925425,0.0003010124,0.0003288234,0.0001338849,0.0003270622,0.0002338302,0.0003709861,0.0004247745,0.001294716],"category_scores_gemma":[0.000158846,0.0001690527,0.0003410649,0.0001236169,0.0002541344,0.000170818,0.0002498121,0.0003779812,0.0005822828],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005937707,"about_ca_system_score_gemma":0.0004266743,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001714793,"about_ca_topic_score_gemma":0.001346682,"domain_scores_codex":[0.9999343,0.00001053334,0.000006044959,0.00001521083,0.00002141851,0.00001241892],"domain_scores_gemma":[0.999918,0.000009312746,0.00002549412,0.000007955789,0.00001029221,0.0000289424],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003558539,0.0001066378,0.002377199,0.0001010628,0.00002789904,0.0006869177,0.00007637374,0.002663998,0.9886383,0.002717723,0.0002433494,0.002004779],"study_design_scores_gemma":[0.0004396187,0.001316514,0.09175821,0.0001166032,0.0001401914,0.003882195,0.0003271151,0.08116098,0.8004881,0.005758058,0.01453024,0.00008224687],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923837,0.001039009,0.003394689,0.0001457926,0.00003922107,0.00004777578,0.0001686901,0.00007999656,0.00270119],"genre_scores_gemma":[0.9966539,0.0002240585,0.001933544,0.0001160419,0.00001015276,0.00001588764,0.0004453954,0.00001107402,0.0005899965],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001714793,"threshold_uncertainty_score":0.004331231,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1592025313672796,"score_gpt":0.3315143889665895,"score_spread":0.1723118575993099,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}