{"id":"W2140081746","doi":"10.2119/molmed.2010.00214","title":"S1P Is Associated with Protection in Human and Experimental Cerebral Malaria","year":2011,"lang":"en","type":"article","venue":"Molecular Medicine","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; Toronto General Hospital; Centre for Global Health Research; University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research","keywords":"Plasmodium berghei; Cerebral Malaria; Sphingosine-1-phosphate; Inflammation; Endothelial activation; Sphingosine; Immunology; Evans Blue; Endothelial stem cell; Sphingolipid; Biology; Pharmacology; Medicine; Cancer research; Cell biology; Malaria; Plasmodium falciparum; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001699587,0.0001278144,0.000154593,0.00006037189,0.00004586967,0.000005113934,0.00006655716,0.0001005192,0.0000809768],"category_scores_gemma":[0.00003846674,0.0001030233,0.00001972637,0.0000907506,0.00009869543,0.000003654274,0.00003856471,0.00008948963,5.582134e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009163839,"about_ca_system_score_gemma":0.00001341295,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002346105,"about_ca_topic_score_gemma":0.00002226093,"domain_scores_codex":[0.9992475,0.00005072572,0.0001425652,0.0002670645,0.0001213003,0.0001708802],"domain_scores_gemma":[0.9996948,0.000001393683,0.00005498127,0.0001559164,0.00002910041,0.00006379018],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006535171,0.00005116076,0.002444464,0.000004847927,0.00003181682,0.00002568554,0.0006782946,0.000001118053,0.996401,0.0001736351,0.00002759214,0.00009502731],"study_design_scores_gemma":[0.002365913,0.0006535389,0.03067991,0.00006089471,0.00002472788,0.00002327792,0.0002674528,0.00003027412,0.9653997,0.00006739392,0.0002763805,0.000150587],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966877,0.0008293505,0.0008225081,0.00008701791,0.00005117936,0.0002062838,0.000001600188,0.00001072177,0.001303616],"genre_scores_gemma":[0.9990959,0.00000551531,0.0001544544,0.0004799774,0.00008120721,0.00002932597,0.00003440113,0.00002036499,0.00009889384],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03100135,"threshold_uncertainty_score":0.4201167,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01699218141347817,"score_gpt":0.2419407802715664,"score_spread":0.2249485988580883,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}