{"id":"W2140133890","doi":"10.4049/jimmunol.1102610","title":"Clonotype and Repertoire Changes Drive the Functional Improvement of HIV-Specific CD8 T Cell Populations under Conditions of Limited Antigenic Stimulation","year":2011,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Royal Victoria Hospital; Institute of Infection and Immunity; McGill University Health Centre; Université de Montréal","funders":"Canadian Institutes of Health Research; National Institute on Drug Abuse; U.S. Public Health Service; Styrelsen för Internationellt Utvecklingssamarbete","keywords":"Biology; CD8; Interleukin-7 receptor; Epitope; Cytotoxic T cell; T-cell receptor; Immunology; T cell; Phenotype; Antigen; Repertoire; CD28; Stimulation; Immune system; Virology; Cell biology; Genetics; Neuroscience; In vitro; Gene; IL-2 receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001413475,0.00009575353,0.0001443402,0.0001480242,0.0001367419,0.0002774629,0.0001130469,0.0001596552,0.0007233691],"category_scores_gemma":[0.000228642,0.0001031771,0.000114853,0.0001026973,0.0001533154,0.0001868303,0.0001800479,0.0003449295,0.0001681094],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001463919,"about_ca_system_score_gemma":0.0001568209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002792445,"about_ca_topic_score_gemma":0.000498106,"domain_scores_codex":[0.9998901,0.00001609322,0.000007155407,0.00001999471,0.00002658767,0.00004013477],"domain_scores_gemma":[0.9998696,0.0000225296,0.00002857168,0.0000224196,0.00002530864,0.00003151881],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000086222,0.0000258332,0.003895492,0.00001080713,0.000002986061,0.00003426363,0.00003561185,0.00007134298,0.9928657,0.00006102126,0.00001615931,0.002894691],"study_design_scores_gemma":[0.00002634887,0.0010717,0.1634796,0.00001312343,0.0000433623,0.001411669,0.0002165276,0.003122842,0.8283726,0.000309066,0.001921381,0.0000116601],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992247,0.000172127,0.0003889359,0.00001082038,0.000001266036,0.000003918129,0.00002631513,0.000006856827,0.0001651221],"genre_scores_gemma":[0.9991597,0.00009590376,0.0003341712,0.00001378388,0.00000268741,0.000008397873,0.00007536588,0.000003316019,0.0003067551],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007233691,"threshold_uncertainty_score":0.002419889,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05218820170965248,"score_gpt":0.2579694581928785,"score_spread":0.205781256483226,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}