{"id":"W2140139281","doi":"10.1016/j.neuron.2006.01.022","title":"Bone Marrow-Derived Microglia Play a Critical Role in Restricting Senile Plaque Formation in Alzheimer's Disease","year":2006,"lang":"en","type":"article","venue":"Neuron","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":1262,"is_retracted":false,"has_abstract":false,"ca_institutions":"Wilfrid Laurier University; Université Laval","funders":"Canadian Institutes of Health Research; Université Laval","keywords":"Microglia; Senile plaques; Genetically modified mouse; Bone marrow; Immune system; Transgene; Integrin alpha M; Amyloid (mycology); Alzheimer's disease; Biology; Cell biology; Pathology; Immunology; Neuroscience; Medicine; Disease; Inflammation; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004158098,0.000425464,0.0004568456,0.0003543953,0.0003753803,0.0005076327,0.0002281832,0.0003933468,0.001382567],"category_scores_gemma":[0.0002433672,0.0001687264,0.000176852,0.0001064956,0.000273883,0.0003042317,0.0003948375,0.0005102577,0.0003714571],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001869944,"about_ca_system_score_gemma":0.0002483442,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000341373,"about_ca_topic_score_gemma":0.0008328747,"domain_scores_codex":[0.9998571,0.00004282495,0.00001164389,0.0000136537,0.00003162886,0.0000431164],"domain_scores_gemma":[0.9998941,0.00001422648,0.00002170205,0.00001061698,0.00002552012,0.00003375075],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001126089,0.000126966,0.001090339,0.0001967721,0.00002425411,0.0004886811,0.0001032461,0.0001064794,0.9793657,0.001249714,0.0003840514,0.01573772],"study_design_scores_gemma":[0.000360241,0.001764092,0.05438311,0.0001896306,0.00035581,0.003833835,0.0005794797,0.001062297,0.9114599,0.005179815,0.02080178,0.0000301351],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9536579,0.03791874,0.003916514,0.0005690042,0.00012863,0.00004689081,0.000199842,0.0000989666,0.003463503],"genre_scores_gemma":[0.9854166,0.007770888,0.003576184,0.0001778312,0.000115673,0.0000623665,0.00013078,0.00002707847,0.00272257],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001382567,"threshold_uncertainty_score":0.004625142,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02199368340329814,"score_gpt":0.2574035869225675,"score_spread":0.2354099035192694,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}