{"id":"W2140154699","doi":"10.1900/rds.2007.4.25","title":"Endoplasmic Reticulum Stress Caused by Overexpression of Islet-Specific Glucose-6-Phosphatase Catalytic Subunit-Related Protein in Pancreatic Beta-Cells","year":2007,"lang":"en","type":"article","venue":"The Review of Diabetic Studies","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity; University of Calgary","funders":"Canadian Institutes of Health Research; Alberta Heritage Foundation for Medical Research; Fondation pour la Recherche Médicale; Canadian Diabetes Association","keywords":"Endoplasmic reticulum; Unfolded protein response; Beta cell; NOD mice; Biology; KDEL; Transgene; Endocrinology; Cell biology; Internal medicine; Pancreatic islets; Islet; Insulin; Biochemistry; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001489277,0.000341414,0.001624616,0.0001393687,0.00006709378,0.000004705149,0.000202657,0.00008798177,0.0001969774],"category_scores_gemma":[0.0008483239,0.0002102113,0.0002099638,0.0007111654,0.0006546286,0.00005422244,0.0001054793,0.0002674001,0.0000475703],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009251311,"about_ca_system_score_gemma":0.00006175286,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006220814,"about_ca_topic_score_gemma":0.000003300606,"domain_scores_codex":[0.997095,0.0002301419,0.001350074,0.0003294861,0.0005498825,0.0004453759],"domain_scores_gemma":[0.9972011,0.001079267,0.0005979086,0.0007611068,0.0002463644,0.000114222],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005227843,0.002873524,0.02267927,0.1093966,0.002858234,0.00007572871,0.003106254,0.000008357622,0.806174,0.002136181,0.03670736,0.01346167],"study_design_scores_gemma":[0.002282426,0.0002922554,0.002810624,0.05654569,0.000753072,0.000003423234,0.001083479,0.00001805977,0.9341497,0.00008263315,0.001762514,0.0002160981],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5981119,0.3993911,0.000002303305,0.0004338346,0.00007473257,0.001318543,0.00006212977,0.00001979365,0.0005856403],"genre_scores_gemma":[0.8669974,0.1320519,0.00008703976,0.0002219217,0.00002584939,0.0001016103,0.00008336706,0.00003132072,0.0003995956],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2688855,"threshold_uncertainty_score":0.8572168,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01878863033945931,"score_gpt":0.2763198286203485,"score_spread":0.2575311982808892,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}