{"id":"W2140204893","doi":"10.1158/1940-6207.capr-11-0536","title":"Metformin Reduces Endogenous Reactive Oxygen Species and Associated DNA Damage","year":2012,"lang":"en","type":"article","venue":"Cancer Prevention Research","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":372,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Jewish General Hospital","funders":"","keywords":"Metformin; Reactive oxygen species; DNA damage; Endogeny; Mitochondrial ROS; Cancer; Pharmacology; Paraquat; Endocrinology; Biology; Insulin; Internal medicine; Chemistry; Cancer research; Medicine; Cell biology; Biochemistry; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001824839,0.0003093725,0.0002750391,0.0003912551,0.0001319918,0.0002320917,0.0001958464,0.0003112134,0.001157085],"category_scores_gemma":[0.0003827351,0.00009256207,0.0001563135,0.0001385582,0.0001311556,0.0001905105,0.0001986973,0.0003678923,0.0001615954],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000188676,"about_ca_system_score_gemma":0.000261914,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003224491,"about_ca_topic_score_gemma":0.0006845763,"domain_scores_codex":[0.9998753,0.00003313403,0.00001070918,0.00001478432,0.00003758432,0.00002851465],"domain_scores_gemma":[0.9997441,0.00003597681,0.0001128333,0.00001948424,0.00004129264,0.00004629375],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001706408,0.0004202265,0.001669205,0.0001774977,0.00004790967,0.00007952514,0.00002253655,0.0002766641,0.9675918,0.0003852589,0.0002320997,0.02739085],"study_design_scores_gemma":[0.0001667491,0.004485536,0.01565243,0.00002254239,0.000074682,0.0002706866,0.00002971084,0.001085481,0.9720253,0.0002939469,0.005882194,0.0000105836],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.984387,0.009096014,0.003249631,0.0003259902,0.0001119982,0.00004704851,0.0001779664,0.0001658523,0.002438591],"genre_scores_gemma":[0.9918793,0.003296033,0.002436611,0.0001228827,0.00005922837,0.00003173932,0.000194708,0.00002023189,0.0019592],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001157085,"threshold_uncertainty_score":0.003870785,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1274211645665924,"score_gpt":0.3877851396724458,"score_spread":0.2603639751058534,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}