{"id":"W2140211771","doi":"10.1371/journal.pone.0096863","title":"Incretin Receptor Null Mice Reveal Key Role of GLP-1 but Not GIP in Pancreatic Beta Cell Adaptation to Pregnancy","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Lunenfeld-Tanenbaum Research Institute","funders":"Banting and Best Diabetes Centre, University of Toronto; Canadian Institutes of Health Research; Canada Research Chairs; European Foundation for the Study of Diabetes; Novo Nordisk; Department of Education and Learning, Northern Ireland","keywords":"Incretin; Endocrinology; Internal medicine; Islet; Gastric inhibitory polypeptide; Beta cell; Glucagon-like peptide-1; Receptor; Alpha cell; Enteroendocrine cell; Glucagon; Biology; Pancreatic islets; Proglucagon; Glucagon-like peptide 1 receptor; Insulin; Hormone; Type 2 diabetes; Diabetes mellitus; Medicine; Endocrine system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003022046,0.000712969,0.0004369994,0.0009227945,0.0001937262,0.0007070286,0.0006486013,0.0007368097,0.002532271],"category_scores_gemma":[0.0003649537,0.0006970044,0.0004009698,0.0002426966,0.0007692896,0.00046943,0.0004212503,0.001962497,0.0004673552],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00030404,"about_ca_system_score_gemma":0.0002446292,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004020784,"about_ca_topic_score_gemma":0.0005379735,"domain_scores_codex":[0.9996926,0.0000428568,0.00003367952,0.00009385519,0.00006571516,0.00007140576],"domain_scores_gemma":[0.9994873,0.00009508066,0.0001971115,0.00005989546,0.00001839114,0.0001423385],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003604288,0.00002652973,0.000308285,0.00002557295,0.000005392577,0.0002410459,0.00002934703,0.0000407874,0.997815,0.0002017992,0.00002382509,0.0009219957],"study_design_scores_gemma":[0.0001615468,0.0007881433,0.03352196,0.0000554605,0.0001234192,0.003836824,0.0002076533,0.001017652,0.9563654,0.0005854375,0.003300501,0.00003598295],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935448,0.001114596,0.002928793,0.0002160342,0.00004010682,0.00001744669,0.0007444808,0.0001352668,0.001258427],"genre_scores_gemma":[0.9868835,0.002194933,0.004213888,0.0001604394,0.00002876676,0.00007863633,0.0007577871,0.0001685188,0.005513479],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002532271,"threshold_uncertainty_score":0.00847131,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02492698039229935,"score_gpt":0.2140252393265571,"score_spread":0.1890982589342578,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}