{"id":"W2140211771","doi":"10.1371/journal.pone.0096863","title":"Incretin Receptor Null Mice Reveal Key Role of GLP-1 but Not GIP in Pancreatic Beta Cell Adaptation to Pregnancy","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Lunenfeld-Tanenbaum Research Institute","funders":"Banting and Best Diabetes Centre, University of Toronto; Canadian Institutes of Health Research; Canada Research Chairs; European Foundation for the Study of Diabetes; Novo Nordisk; Department of Education and Learning, Northern Ireland","keywords":"Incretin; Endocrinology; Internal medicine; Islet; Gastric inhibitory polypeptide; Beta cell; Glucagon-like peptide-1; Receptor; Alpha cell; Enteroendocrine cell; Glucagon; Biology; Pancreatic islets; Proglucagon; Glucagon-like peptide 1 receptor; Insulin; Hormone; Type 2 diabetes; Diabetes mellitus; Medicine; Endocrine system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00026168,0.0001519814,0.000545366,0.000166705,0.00002461882,0.000007840282,0.00008605151,0.0001006452,0.0003087695],"category_scores_gemma":[0.0008208735,0.000145552,0.00005100599,0.0002512629,0.00004027673,0.00006167185,0.00003166784,0.0001430047,0.000375448],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006462426,"about_ca_system_score_gemma":0.00005839473,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005759398,"about_ca_topic_score_gemma":0.00002533615,"domain_scores_codex":[0.9985673,0.0001221494,0.0004171294,0.0002702293,0.000376236,0.0002469998],"domain_scores_gemma":[0.9989415,0.0002799965,0.0001363143,0.000318133,0.000147883,0.00017616],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004036689,0.001027759,0.04853129,0.0006402716,0.00006194047,0.000001062592,0.001416848,0.000006483631,0.9462817,0.0001191521,0.0002886448,0.001221213],"study_design_scores_gemma":[0.00249871,0.001019978,0.04103304,0.003200807,0.0003328691,6.959786e-7,0.000519241,0.001648701,0.9490937,0.00008124825,0.0003644962,0.0002065298],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9868854,0.0004203865,0.00006355216,0.0006860045,0.00003669084,0.0006011662,0.0000208145,0.00005125983,0.01123467],"genre_scores_gemma":[0.9809315,0.00005877982,0.01417174,0.0004886628,0.000123128,0.00008403248,0.00005933485,0.00002752041,0.00405535],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01410819,"threshold_uncertainty_score":0.5935437,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02492698039229935,"score_gpt":0.2140252393265571,"score_spread":0.1890982589342578,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}