{"id":"W2140263133","doi":"10.1021/ja067211+","title":"Exiguamine A, an Indoleamine-2,3-dioxygenase (IDO) Inhibitor Isolated from the Marine Sponge <i>Neopetrosia </i><i>exigua</i>","year":2006,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":125,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Chemistry; Exigua; Sponge; Indoleamine 2,3-dioxygenase; Stereochemistry; Biogenesis; In vitro; Skeleton (computer programming); Carbon skeleton; Tryptophan; Biochemistry; Botany; Spodoptera; Gene; Biology; Anatomy; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004868876,0.0002702624,0.0001601179,0.0002152222,0.0001397846,0.0001447715,0.0001363541,0.0001875401,0.0006247971],"category_scores_gemma":[0.00007116971,0.00007107455,0.0001895854,0.0001246574,0.0001546834,0.0001448575,0.0001823904,0.0002418364,0.0001453989],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001383969,"about_ca_system_score_gemma":0.0001678998,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005239492,"about_ca_topic_score_gemma":0.001290071,"domain_scores_codex":[0.9999801,0.000002858864,0.000001794476,0.000005179687,0.000005146127,0.000004967518],"domain_scores_gemma":[0.9999698,0.000003745903,0.000008029921,0.000002906423,0.000004102417,0.00001146518],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001676207,0.00003055967,0.0009824701,0.000137275,0.00001891738,0.0003365479,0.00002377827,0.0001181879,0.9869912,0.0001066272,0.00007154544,0.01101528],"study_design_scores_gemma":[0.00007245732,0.001402525,0.01779105,0.000035331,0.00005750291,0.003881726,0.00008096151,0.0007471206,0.9569924,0.0001779314,0.01874046,0.00002056741],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.980355,0.009203603,0.005190416,0.0001654081,0.00005064518,0.00007295599,0.0006377292,0.00009095326,0.004233443],"genre_scores_gemma":[0.9883239,0.003984109,0.004830655,0.00008719364,0.0000200436,0.00001944207,0.0008441283,0.00001002091,0.001880496],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006247971,"threshold_uncertainty_score":0.002090156,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0101706035844304,"score_gpt":0.2295981490443652,"score_spread":0.2194275454599348,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}