{"id":"W2140263133","doi":"10.1021/ja067211+","title":"Exiguamine A, an Indoleamine-2,3-dioxygenase (IDO) Inhibitor Isolated from the Marine Sponge <i>Neopetrosia </i><i>exigua</i>","year":2006,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":125,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Chemistry; Exigua; Sponge; Indoleamine 2,3-dioxygenase; Stereochemistry; Biogenesis; In vitro; Skeleton (computer programming); Carbon skeleton; Tryptophan; Biochemistry; Botany; Spodoptera; Gene; Biology; Anatomy; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002806503,0.0003002775,0.000456811,0.00001985382,0.0002395502,0.0001176332,0.001376654,0.00008526332,0.00008973125],"category_scores_gemma":[0.0003267911,0.0001665444,0.0006895853,0.0008547024,0.0009796249,0.0002453158,0.0003497354,0.0008828202,0.00001310723],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001298615,"about_ca_system_score_gemma":0.00009303392,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004677156,"about_ca_topic_score_gemma":0.00002054244,"domain_scores_codex":[0.9975991,0.0002400621,0.0006341926,0.0003562314,0.0007078277,0.0004626003],"domain_scores_gemma":[0.9976897,0.0005438854,0.0009597561,0.0005527563,0.00008907574,0.0001648075],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002166016,0.0003269891,0.001189019,0.000003388259,0.00002339494,0.00001292356,0.0002069272,0.00002089003,0.9692416,0.00001891393,0.02693298,0.001806387],"study_design_scores_gemma":[0.00130718,0.000193514,0.01822584,0.00002809112,0.00003017882,0.0001010835,0.000463024,0.0003528018,0.9708194,0.0006497721,0.007551203,0.000277936],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957398,0.0001159203,0.00007793082,0.003256075,0.0002532979,0.0001465055,0.00004770881,0.00004498361,0.0003178302],"genre_scores_gemma":[0.9876043,0.00007529739,0.0006941496,0.01011106,0.001265915,0.000003535564,0.000005891741,0.00004310502,0.0001967787],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01938177,"threshold_uncertainty_score":0.6791481,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0101706035844304,"score_gpt":0.2295981490443652,"score_spread":0.2194275454599348,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}