{"id":"W2140287543","doi":"10.1158/1078-0432.ccr-05-1170","title":"Mcl-1, Vascular Endothelial Growth Factor-R2, and 14-3-3σ Expression Might Predict Primary Response against Radiotherapy and Chemotherapy in Patients with Locally Advanced Squamous Cell Carcinomas of the Head and Neck","year":2005,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"14-3-3 protein interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Radiation therapy; Medicine; Chemotherapy; Concomitant; Head and neck cancer; Cisplatin; Epidermoid carcinoma; Vascular endothelial growth factor; Immunohistochemistry; Pathology; Oncology; Cancer; Internal medicine; Primary tumor; Head and neck squamous-cell carcinoma; Metastasis; VEGF receptors","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002546408,0.0002152772,0.0002580034,0.0002567216,0.0001861161,0.0001846704,0.0001375293,0.0002776259,0.0009040409],"category_scores_gemma":[0.0006963046,0.0001201186,0.0001802497,0.0001355567,0.0002172915,0.0001355166,0.0001407506,0.0002073543,0.0001899294],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002020412,"about_ca_system_score_gemma":0.0001606002,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005287666,"about_ca_topic_score_gemma":0.0008445736,"domain_scores_codex":[0.999893,0.00002928168,0.00001119303,0.00002311193,0.00001994905,0.00002349551],"domain_scores_gemma":[0.999696,0.0001056659,0.00009043307,0.00001538843,0.00002646953,0.00006604625],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008581744,0.00006219731,0.986807,0.00002317007,0.00003938539,0.0001533549,0.00004796304,0.0002128305,0.007537976,0.000006160007,0.00006147972,0.004190179],"study_design_scores_gemma":[0.00004351846,0.0008826468,0.9951279,0.000004187586,0.0000524035,0.000972129,0.00008851761,0.0006621515,0.001966329,0.00001642228,0.0001804905,0.000003421921],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9997135,0.000155177,0.00005137673,0.000008948872,0.000001228281,0.000003433155,0.00001976185,0.000001528681,0.00004506134],"genre_scores_gemma":[0.9997793,0.00003222877,0.00006702329,0.00000769075,0.000003911979,0.000005090955,0.00005883746,3.949524e-7,0.00004547379],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009040409,"threshold_uncertainty_score":0.00302434,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02026420178363875,"score_gpt":0.3453388101488503,"score_spread":0.3250746083652115,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}