{"id":"W2140288479","doi":"10.1093/carcin/bgm187","title":"Biotransformation and transport of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in bile duct-cannulated wild-type and Mrp2/Abcc2-deficient (TR ) Wistar rats","year":2007,"lang":"en","type":"article","venue":"Carcinogenesis","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of General Medical Sciences","keywords":"Carcinogen; Nitrosamine; Biotransformation; Multidrug resistance-associated protein 2; Bile duct; Butanone; Chemistry; Internal medicine; Medicine; Pharmacology; Biochemistry; ATP-binding cassette transporter; Transporter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008330208,0.0003782454,0.0006836827,0.0004028174,0.0001675826,0.00001520459,0.0001720232,0.0002722498,0.00004817514],"category_scores_gemma":[0.00001849492,0.000282364,0.0001607705,0.001376808,0.0003418489,0.0001312689,0.00002365912,0.0002620348,0.000003070061],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001248326,"about_ca_system_score_gemma":0.0001796865,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000267862,"about_ca_topic_score_gemma":0.0005494154,"domain_scores_codex":[0.997392,0.00005940089,0.0008634861,0.000547834,0.0005714857,0.0005658118],"domain_scores_gemma":[0.9987029,0.00006148998,0.0001700419,0.0005441491,0.0002808364,0.0002405571],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0008037534,0.0001615841,0.3866609,0.0003046663,0.00005521424,0.00009602332,0.002177264,0.00003119616,0.6060814,0.0002539859,0.00002315575,0.00335086],"study_design_scores_gemma":[0.00142212,0.0001496611,0.6378348,0.0001581406,0.0001861984,0.00005510001,0.0009958656,0.00002971195,0.3574974,0.00004173529,0.001389532,0.0002396809],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892424,0.008047824,0.0003594939,0.0003328595,0.0003251258,0.001046548,0.00009193258,0.00004769896,0.0005060938],"genre_scores_gemma":[0.9977874,0.001260286,0.000432413,0.0001312548,0.00006265757,0.00001174458,0.0001017529,0.00005168254,0.0001608436],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2511739,"threshold_uncertainty_score":0.9999629,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01237551576147762,"score_gpt":0.2253745472181639,"score_spread":0.2129990314566862,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}