{"id":"W2140288479","doi":"10.1093/carcin/bgm187","title":"Biotransformation and transport of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in bile duct-cannulated wild-type and Mrp2/Abcc2-deficient (TR ) Wistar rats","year":2007,"lang":"en","type":"article","venue":"Carcinogenesis","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of General Medical Sciences","keywords":"Carcinogen; Nitrosamine; Biotransformation; Multidrug resistance-associated protein 2; Bile duct; Butanone; Chemistry; Internal medicine; Medicine; Pharmacology; Biochemistry; ATP-binding cassette transporter; Transporter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002408742,0.0007226102,0.0006034545,0.0007239752,0.0002413048,0.0003693808,0.0003306214,0.00057348,0.001378802],"category_scores_gemma":[0.0002743702,0.0005749149,0.0005788998,0.0003463961,0.0005301173,0.0006785122,0.0002513696,0.000890365,0.0005594522],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006724829,"about_ca_system_score_gemma":0.0004378314,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002841765,"about_ca_topic_score_gemma":0.002738564,"domain_scores_codex":[0.999603,0.00005715371,0.00004032203,0.0001113119,0.00007643163,0.000111971],"domain_scores_gemma":[0.9994924,0.00005081291,0.0001712973,0.00007701456,0.00005998781,0.0001484783],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001532271,0.00009523839,0.000997595,0.00002500632,0.00001933522,0.00008713709,0.00002925686,0.0001099191,0.9961843,0.00006723718,0.00002752724,0.0008251182],"study_design_scores_gemma":[0.00008036096,0.001990681,0.009011655,0.000003649421,0.00008624334,0.0003908246,0.00008986698,0.001103935,0.9865705,0.00007854059,0.0005747706,0.00001896737],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980622,0.0003713247,0.0008586058,0.00004133379,0.00001211006,0.00001077275,0.0003772738,0.0000505273,0.0002158354],"genre_scores_gemma":[0.9912454,0.001000771,0.002687329,0.00004483467,0.00001814695,0.00006452174,0.001280892,0.0000799889,0.003577987],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002841765,"threshold_uncertainty_score":0.005650461,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01237551576147762,"score_gpt":0.2253745472181639,"score_spread":0.2129990314566862,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}