{"id":"W2140320479","doi":"10.15252/emmm.201404077","title":"Efficient transduction and optogenetic stimulation of retinal bipolar cells by a synthetic adeno‐associated virus capsid and promoter","year":2014,"lang":"en","type":"article","venue":"EMBO Molecular Medicine","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":184,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"Perelman School of Medicine, University of Pennsylvania; National Eye Institute; James N. Kirby Foundation; Hope For Vision; University of Pennsylvania; Research to Prevent Blindness; National Center for Chronic Disease Prevention and Health Promotion; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; F. M. Kirby Foundation; National Institutes of Health; National Science Foundation","keywords":"Optogenetics; Transduction (biophysics); Adeno-associated virus; Capsid; Retinal; Biology; Transgene; Cell biology; Neuroscience; Virus; Vector (molecular biology); Virology; Gene; Genetics; Recombinant DNA; Biophysics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002431619,0.000298341,0.0001766188,0.0001472052,0.00009973563,0.0002997343,0.0002436244,0.0002160763,0.0004406262],"category_scores_gemma":[0.0001535849,0.0001698539,0.0002020418,0.00007975099,0.0002302537,0.0001789728,0.0002489648,0.00037893,0.0002133759],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000243597,"about_ca_system_score_gemma":0.0002971939,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004004354,"about_ca_topic_score_gemma":0.0004438779,"domain_scores_codex":[0.9998498,0.00001993374,0.00001538937,0.00003020518,0.00005843127,0.00002628309],"domain_scores_gemma":[0.9999044,0.00001838554,0.00003349854,0.00001111122,0.0000106183,0.00002198237],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001373037,0.000006974142,0.000043418,0.0000205564,0.000001644485,0.00002594012,0.00001065993,0.0000818664,0.9984995,0.0002450212,0.00001705883,0.00103366],"study_design_scores_gemma":[0.00001366998,0.0001556315,0.0007018532,0.000008775826,0.00001195499,0.0003868957,0.000013239,0.001546403,0.9906477,0.00008449926,0.006422559,0.000006757262],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.858458,0.002498636,0.1328841,0.0002285207,0.0002313018,0.0002982623,0.0004684208,0.000326745,0.004606048],"genre_scores_gemma":[0.9130498,0.001882526,0.08028628,0.00006557185,0.0000300207,0.0001376539,0.0005283175,0.00009587823,0.003923893],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004406262,"threshold_uncertainty_score":0.001767457,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003798385123260653,"score_gpt":0.2129990546390934,"score_spread":0.2092006695158328,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}