{"id":"W2140320479","doi":"10.15252/emmm.201404077","title":"Efficient transduction and optogenetic stimulation of retinal bipolar cells by a synthetic adeno‐associated virus capsid and promoter","year":2014,"lang":"en","type":"article","venue":"EMBO Molecular Medicine","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":184,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"Perelman School of Medicine, University of Pennsylvania; National Eye Institute; James N. Kirby Foundation; Hope For Vision; University of Pennsylvania; Research to Prevent Blindness; National Center for Chronic Disease Prevention and Health Promotion; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; F. M. Kirby Foundation; National Institutes of Health; National Science Foundation","keywords":"Optogenetics; Transduction (biophysics); Adeno-associated virus; Capsid; Retinal; Biology; Transgene; Cell biology; Neuroscience; Virus; Vector (molecular biology); Virology; Gene; Genetics; Recombinant DNA; Biophysics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003009228,0.0001589844,0.000197652,0.00006033363,0.00004819896,0.000006436103,0.00005931196,0.0001175974,0.00002585515],"category_scores_gemma":[0.0001162503,0.0001395323,0.00002997341,0.00008745684,0.0001943768,0.000001498113,0.00002730605,0.00006228806,8.851866e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007143477,"about_ca_system_score_gemma":0.00001640806,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003542731,"about_ca_topic_score_gemma":0.000003909578,"domain_scores_codex":[0.9989614,0.0001140845,0.0002407114,0.0003143676,0.0002004455,0.0001690283],"domain_scores_gemma":[0.9995904,0.00001273055,0.0001003069,0.0001469489,0.0000618018,0.00008779522],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007125016,0.00004700363,0.0006801427,0.00004702453,0.00003286995,0.000001134712,0.0001859014,0.0001331558,0.9958806,0.00001398414,0.0001393872,0.002767545],"study_design_scores_gemma":[0.001845378,0.001145158,0.01016144,0.0001263401,0.0001331599,0.00001698948,0.00006975437,0.002783176,0.9802203,0.00008334648,0.003152156,0.0002628528],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867434,0.004926527,0.007520895,0.0002815848,0.0000643614,0.000234926,0.000005303187,0.000008101399,0.0002148964],"genre_scores_gemma":[0.9990916,0.0002818191,0.0002848717,0.0001128963,0.00002747438,0.000007689089,0.00008820189,0.00001937619,0.00008603397],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01566035,"threshold_uncertainty_score":0.5689964,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003798385123260653,"score_gpt":0.2129990546390934,"score_spread":0.2092006695158328,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}