{"id":"W2140328575","doi":"10.1189/jlb.0513281","title":"Rac1 and Rac2 control distinct events during antigen-stimulated mast cell exocytosis","year":2014,"lang":"en","type":"article","venue":"Journal of Leukocyte Biology","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Faculty of Medicine and Dentistry, University of Alberta; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Exocytosis; Membrane ruffling; Cell biology; Biology; RAC1; Calcium in biology; Mast cell; Calcium signaling; Rac GTP-Binding Proteins; Calcium; Intracellular; Signal transduction; Secretion; Cell; Biochemistry; Immunology; Chemistry; Cytoskeleton","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001793947,0.0003342244,0.0002765238,0.0002261459,0.0002406966,0.0004720116,0.000197791,0.0003709741,0.001327929],"category_scores_gemma":[0.000128619,0.0002074149,0.0003977115,0.0001195867,0.0002180071,0.0004002295,0.0002667557,0.0005678553,0.0004746896],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000265141,"about_ca_system_score_gemma":0.0001145785,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002194918,"about_ca_topic_score_gemma":0.0002481551,"domain_scores_codex":[0.9997439,0.00004499627,0.00002474067,0.00004944929,0.00004966925,0.00008722639],"domain_scores_gemma":[0.9998822,0.00001805522,0.00003375353,0.00001404085,0.00001788112,0.00003401953],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001131277,0.000008952969,0.00009342482,0.00001296057,0.000001546932,0.00003056572,0.000009228449,0.0000188108,0.9993768,0.00007368112,0.0000121613,0.0002486484],"study_design_scores_gemma":[0.0000297422,0.0001171802,0.01546288,0.000006509481,0.00001401508,0.0002924758,0.00006521377,0.002583174,0.9800584,0.0000733393,0.001288874,0.000008182975],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965953,0.0008194805,0.001610914,0.00005508016,0.00001386403,0.00001656531,0.0001875624,0.00003853663,0.000662667],"genre_scores_gemma":[0.9962643,0.0004069594,0.001377721,0.0000322774,0.00001108182,0.0000354981,0.000259798,0.00002100751,0.001591488],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001327929,"threshold_uncertainty_score":0.004442394,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005705079018684459,"score_gpt":0.2078677353412632,"score_spread":0.2021626563225787,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}