{"id":"W2140345256","doi":"10.1016/j.molcel.2013.11.003","title":"DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities","year":2013,"lang":"en","type":"article","venue":"Molecular Cell","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":567,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Hôtel-Dieu de Québec; University of Toronto","funders":"National Institute of General Medical Sciences; National Institute for Health and Care Research; Canadian Institutes of Health Research; National Cancer Institute; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Wellcome Trust","keywords":"Biology; Exonuclease; Rad50; Nuclease; DNA repair; Replication protein A; Homologous recombination; Endonuclease; Non-homologous end joining; Chromatin; Cell biology; DNA repair protein XRCC4; DNA; Genetics; Molecular biology; DNA mismatch repair; DNA-binding protein; Polymerase; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001073712,0.0003875471,0.0002644091,0.00004651446,0.0001184314,0.00008982157,0.0003242307,0.0002893606,0.0004580234],"category_scores_gemma":[0.00003152347,0.0003907906,0.0003113441,0.0001247051,0.00009736752,0.00001478673,0.0001859689,0.0001625766,0.000155979],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002931906,"about_ca_system_score_gemma":0.00006545375,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003151632,"about_ca_topic_score_gemma":0.00002396604,"domain_scores_codex":[0.9980239,0.0001035102,0.0002845455,0.0007733999,0.0002875504,0.0005271284],"domain_scores_gemma":[0.9986236,0.00001626978,0.0001245347,0.0008792127,0.00009319051,0.0002631562],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006579355,0.000189015,0.0002478791,0.00004865184,0.00007619883,0.00002401064,0.00004596135,0.000002649864,0.972396,0.00001471074,0.02603015,0.0008590474],"study_design_scores_gemma":[0.001243641,0.0002099272,0.0001737863,0.00001219464,0.00003909519,0.000009113059,0.00003908908,0.0001458911,0.8890733,0.00004282208,0.1085696,0.0004415384],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.980813,0.0007958972,0.000763531,0.0001261776,0.0001571621,0.000552669,0.0001074148,0.0002522734,0.01643194],"genre_scores_gemma":[0.9885395,0.00002836938,0.0008967598,0.0008164435,0.00009665609,0.0001204788,0.0003302763,0.0001067028,0.009064821],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08332264,"threshold_uncertainty_score":0.9998544,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004843619110035483,"score_gpt":0.1976260333571322,"score_spread":0.1927824142470968,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}