{"id":"W2140346195","doi":"10.2337/db10-0440","title":"SUMOylation Regulates Insulin Exocytosis Downstream of Secretory Granule Docking in Rodents and Humans","year":2011,"lang":"en","type":"article","venue":"Diabetes","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of Alberta","funders":"Canadian Institutes of Health Research; University of Alberta; Alberta Diabetes Foundation; Alberta Heritage Foundation for Medical Research; Fondation pour la Recherche Médicale; Canadian Diabetes Association","keywords":"Exocytosis; Cell biology; Secretion; Biology; Synaptotagmin 1; SUMO protein; Insulin; Internal medicine; Endocrinology; Biochemistry; Synaptic vesicle; Vesicle; Ubiquitin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001408521,0.00008860446,0.0001151112,0.00005586485,0.00002752456,0.000006327545,0.00007553475,0.00009310067,0.00002677407],"category_scores_gemma":[0.00003536684,0.00008781291,0.00003111293,0.00005385492,0.00007949215,0.000005611297,0.00005605419,0.00004324962,0.000001750129],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004639699,"about_ca_system_score_gemma":0.00001156309,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003550149,"about_ca_topic_score_gemma":0.00002488357,"domain_scores_codex":[0.9994196,0.00004134381,0.0001562577,0.0001814238,0.00005779645,0.0001435569],"domain_scores_gemma":[0.9997146,0.000008678923,0.00006683189,0.0001485011,0.00002901159,0.00003240904],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001505948,0.00003794752,0.3700017,0.00003879803,0.00001325392,3.621911e-7,0.0003796871,0.000002573721,0.6259815,0.00006991301,0.00001311613,0.003446088],"study_design_scores_gemma":[0.0002836544,0.0001002126,0.1549696,0.00003598996,0.000006177472,2.175406e-7,0.00005199705,0.0000357936,0.8438258,0.0004821715,0.0001190166,0.00008942285],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972458,0.001223227,0.000008004162,0.000004494245,0.00003227409,0.0001084217,0.00001521581,0.000007018619,0.001355503],"genre_scores_gemma":[0.9994817,0.000114712,0.0002306792,0.00002530742,0.00003282171,0.00001609027,0.00006282861,0.0000102105,0.00002558433],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2178442,"threshold_uncertainty_score":0.3580906,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01837474781335225,"score_gpt":0.2185016529286178,"score_spread":0.2001269051152655,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}