{"id":"W2140346195","doi":"10.2337/db10-0440","title":"SUMOylation Regulates Insulin Exocytosis Downstream of Secretory Granule Docking in Rodents and Humans","year":2011,"lang":"en","type":"article","venue":"Diabetes","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of Alberta","funders":"Canadian Institutes of Health Research; University of Alberta; Alberta Diabetes Foundation; Alberta Heritage Foundation for Medical Research; Fondation pour la Recherche Médicale; Canadian Diabetes Association","keywords":"Exocytosis; Cell biology; Secretion; Biology; Synaptotagmin 1; SUMO protein; Insulin; Internal medicine; Endocrinology; Biochemistry; Synaptic vesicle; Vesicle; Ubiquitin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001899491,0.0004104183,0.0002300553,0.0005563025,0.0002018786,0.0003405053,0.000138407,0.0002814187,0.001991929],"category_scores_gemma":[0.0002377441,0.0001429317,0.0002381266,0.0002257788,0.0005095932,0.0002052242,0.0002903166,0.0002243353,0.0001950092],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001942874,"about_ca_system_score_gemma":0.0000674919,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002035915,"about_ca_topic_score_gemma":0.0002123633,"domain_scores_codex":[0.9998909,0.00002044385,0.000009848456,0.00005127394,0.00001299596,0.00001450686],"domain_scores_gemma":[0.9998919,0.00001053645,0.00005040061,0.00001373123,0.000007527045,0.00002596673],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009237816,0.0005013937,0.3985571,0.0002821053,0.0006450421,0.007972928,0.00028072,0.0005876195,0.4723505,0.003712504,0.002777131,0.1030952],"study_design_scores_gemma":[0.000187278,0.001509016,0.9564177,0.00005467442,0.0001666543,0.01350675,0.0001559158,0.0003833716,0.01975212,0.001518241,0.006320712,0.00002749029],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946916,0.002031446,0.001215277,0.0001406335,0.0000229101,0.00002013224,0.0003559442,0.00007009642,0.001451917],"genre_scores_gemma":[0.9969021,0.001060559,0.000820017,0.0001061624,0.00001539078,0.00001572834,0.0003343548,0.00001215781,0.0007334676],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001991929,"threshold_uncertainty_score":0.00666368,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01837474781335225,"score_gpt":0.2185016529286178,"score_spread":0.2001269051152655,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}