{"id":"W2140386129","doi":"10.1073/pnas.0600220103","title":"Long-range cooperative binding effects in a T cell receptor variable domain","year":2006,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"National Institute of General Medical Sciences; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Cooperativity; Mutagenesis; Cooperative binding; Allosteric regulation; Biophysics; Plasma protein binding; Protein structure; Protein domain; Protein–protein interaction; Immunoglobulin domain; Energetics; Alanine scanning; Hot spot (computer programming); Surface plasmon resonance; Biology; Chemistry; Receptor; Mutation; Binding site; Biochemistry; Materials science; Nanotechnology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003693367,0.0003090806,0.0003146923,0.0002211231,0.0004577615,0.000364416,0.0003609784,0.0002552506,0.0008895213],"category_scores_gemma":[0.0005437891,0.0002521898,0.0002588955,0.0001468975,0.00055736,0.0002727245,0.0003909362,0.0003886266,0.0002026937],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000418207,"about_ca_system_score_gemma":0.000167404,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005980756,"about_ca_topic_score_gemma":0.001117614,"domain_scores_codex":[0.9995618,0.0001065964,0.0000186805,0.000085952,0.0001505419,0.00007636268],"domain_scores_gemma":[0.9996262,0.0001811799,0.00007079789,0.00003467117,0.00002695555,0.00006029341],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001799282,0.0001029685,0.001544331,0.00004470348,0.00003647485,0.0002778853,0.00006908344,0.003711149,0.9904717,0.000770945,0.00004743043,0.002743358],"study_design_scores_gemma":[0.00007179113,0.001064348,0.01577781,0.00000927654,0.0001576474,0.001626598,0.0001402552,0.04869701,0.9293974,0.001357059,0.001654876,0.00004588257],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973163,0.0002048512,0.001978274,0.0000194904,0.000002804919,0.000004995381,0.000004038182,0.00002434672,0.000444783],"genre_scores_gemma":[0.9991606,0.00003797641,0.0006270958,0.00001175153,0.000001044872,0.000002780988,0.000006860665,0.000004126259,0.0001477704],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008895213,"threshold_uncertainty_score":0.003034294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02620212048405283,"score_gpt":0.3141595064325019,"score_spread":0.2879573859484491,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}