{"id":"W2140387877","doi":"10.1091/mbc.e04-03-0271","title":"The Complex of Ciliary Neurotrophic Factor-Ciliary Neurotrophic Factor Receptor α Up-Regulates Connexin43 and Intercellular Coupling in Astrocytes via the Janus Tyrosine Kinase/Signal Transducer and Activator of Transcription Pathway","year":2004,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Connexins and lens biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Institutes of Health Research; Western University; University of British Columbia","funders":"","keywords":"Ciliary neurotrophic factor; Biology; Cell biology; Janus kinase; STAT protein; Neurotrophic factors; Signal transduction; Transcription factor; Neurotrophin; Activator (genetics); JAK-STAT signaling pathway; Tyrosine kinase; Receptor tyrosine kinase; STAT3; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001264981,0.0003104051,0.0002627604,0.0002041691,0.000250093,0.0002483182,0.00009005769,0.000204203,0.000826258],"category_scores_gemma":[0.0001236142,0.0001522367,0.0002822213,0.0001483931,0.0001337788,0.0001717154,0.0002322451,0.0003884333,0.0003551412],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002394735,"about_ca_system_score_gemma":0.0001988645,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008492052,"about_ca_topic_score_gemma":0.001666676,"domain_scores_codex":[0.9997794,0.00003836632,0.00002346691,0.0000408479,0.00007500822,0.00004300604],"domain_scores_gemma":[0.9999206,0.000007197278,0.00002132497,0.000009369088,0.00001496908,0.00002650594],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004345037,0.000009763704,0.0001474708,0.00002355068,0.000005652334,0.0000842706,0.00001242684,0.00001577212,0.9988581,0.0000591442,0.0000303338,0.0007100913],"study_design_scores_gemma":[0.00005492698,0.0004415469,0.02850557,0.0000231487,0.00005876906,0.001047355,0.00008749002,0.001385908,0.9578671,0.0001867331,0.01033294,0.000008472608],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9847485,0.008015062,0.003746829,0.0001933461,0.0001133804,0.0000528603,0.0002189398,0.00006961713,0.002841379],"genre_scores_gemma":[0.9904031,0.002573317,0.003198961,0.000102319,0.00002823407,0.00006048509,0.0004592058,0.00002184083,0.003152569],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008492052,"threshold_uncertainty_score":0,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01253830423645257,"score_gpt":0.2183144288340529,"score_spread":0.2057761245976003,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}