{"id":"W2140404076","doi":"10.1124/mol.105.011494","title":"Pharmacological Telomerase Inhibition Can Sensitize Drug-Resistant and Drug-Sensitive Cells to Chemotherapeutic Treatment","year":2005,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Telomerase; Telomere; Drug; Cancer cell; Drug resistance; Ribonucleoprotein; Cancer research; Pharmacology; Biology; Telomerase reverse transcriptase; Cancer; Chemistry; Biochemistry; DNA; RNA; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002016518,0.0004691216,0.0006486566,0.0002791961,0.0001681776,0.00002628715,0.00006889152,0.0001331921,0.0003050462],"category_scores_gemma":[0.00001361559,0.0004182305,0.0001585887,0.000343835,0.0002043921,0.0000531016,0.00007364107,0.0002839425,0.0001380529],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004720274,"about_ca_system_score_gemma":0.0001652639,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001269499,"about_ca_topic_score_gemma":0.00007065579,"domain_scores_codex":[0.9974549,0.0003090799,0.000423692,0.0007922882,0.0002885359,0.0007315478],"domain_scores_gemma":[0.9987186,0.0001198838,0.0001005087,0.0002141242,0.0001538945,0.0006930245],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001128641,0.0006518743,0.00005852583,0.00003084798,0.0003084632,0.002283152,0.001255245,0.00006838123,0.9716575,0.0000221089,0.004383758,0.01815149],"study_design_scores_gemma":[0.005472433,0.0005349187,0.0007473784,0.00002886807,0.0006912382,0.0003142514,0.0002700844,0.0004046907,0.9685233,0.00001007441,0.02259641,0.0004064113],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9718631,0.0005638652,0.0001264217,0.0251269,0.0002858207,0.001362306,0.00004651568,0.0001705742,0.0004545206],"genre_scores_gemma":[0.9611118,0.0003985113,0.001395356,0.03545753,0.0004084713,0.0001013585,0.00004328206,0.00005972525,0.00102395],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01821266,"threshold_uncertainty_score":0.999827,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0117681442834233,"score_gpt":0.2861854120340916,"score_spread":0.2744172677506683,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}