{"id":"W2140446093","doi":"10.1074/jbc.m503144200","title":"Hypoxic Augmentation of Ca2+ Channel Currents Requires a Functional Electron Transport Chain","year":2005,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Mitochondrion; Chemistry; Trolox; Xanthine oxidase; Intracellular; Reactive oxygen species; Biophysics; Cell biology; HEK 293 cells; Biochemistry; Biology; Oxidative stress; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000108825,0.0001341426,0.0001765158,0.00006625755,0.0001259189,0.0002366168,0.0001746909,0.000219815,0.001231384],"category_scores_gemma":[0.0001555424,0.00009329207,0.000192514,0.00009452587,0.000187798,0.0002477773,0.0001793553,0.0002953486,0.0002189943],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000196961,"about_ca_system_score_gemma":0.0001382914,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001003183,"about_ca_topic_score_gemma":0.00110622,"domain_scores_codex":[0.9998941,0.00001105033,0.000009826881,0.00002198609,0.00003101369,0.00003199162],"domain_scores_gemma":[0.9998926,0.00001450524,0.00003272356,0.0000125197,0.00002096896,0.00002658667],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001357197,0.00001596973,0.0001487191,0.00002212997,0.000002492444,0.00003331916,0.00001223902,0.000008977227,0.9991209,0.00003837932,0.00002687999,0.0004342804],"study_design_scores_gemma":[0.00005442232,0.0006970662,0.07177356,0.00001966673,0.00001870665,0.0004892026,0.0001113367,0.000782928,0.9223472,0.0001387564,0.00355975,0.000007364656],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966283,0.001059574,0.0007189799,0.0001389873,0.00002684057,0.00001316251,0.0001317446,0.00002612752,0.001256125],"genre_scores_gemma":[0.9974885,0.0005164097,0.0004212937,0.00007283659,0.00001525072,0.00001477892,0.000253123,0.000005935076,0.001211828],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001231384,"threshold_uncertainty_score":0.004119337,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0513951241928654,"score_gpt":0.3244206138198604,"score_spread":0.273025489626995,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}