{"id":"W2140446413","doi":"10.1074/jbc.275.19.14198","title":"Tyrosine 62 of the γ-Aminobutyric Acid Type A Receptor β2 Subunit Is an Important Determinant of High Affinity Agonist Binding","year":2000,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Muscimol; Allosteric regulation; Agonist; Binding site; Receptor; Biochemistry; Tyrosine; Chemistry; GABAA receptor; Protein subunit; Serine; Gamma-aminobutyric acid receptor subunit alpha-1; Wild type; Molecular biology; Biology; Mutant; G alpha subunit; Phosphorylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001038157,0.0003345732,0.0002118177,0.00006873823,0.0001400416,0.0003310832,0.0001421332,0.0002271179,0.001638767],"category_scores_gemma":[0.0001679124,0.0001415573,0.000133324,0.00006065274,0.0001569524,0.0001848961,0.0001486117,0.0002410109,0.000915383],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001948899,"about_ca_system_score_gemma":0.0001395398,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006238894,"about_ca_topic_score_gemma":0.0006592388,"domain_scores_codex":[0.9999187,0.00001247472,0.000009653108,0.00002142874,0.00001920512,0.00001852714],"domain_scores_gemma":[0.9999143,0.00001094531,0.00003119538,0.000005665552,0.00001192153,0.00002597663],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001584479,0.00001249997,0.001208295,0.00002352915,0.000006253428,0.0001790242,0.00001322986,0.00005868866,0.9965719,0.00008119815,0.00003756063,0.001649328],"study_design_scores_gemma":[0.0001057588,0.0005529786,0.05391795,0.00003018665,0.00005161524,0.002828916,0.00009825341,0.002154139,0.9349452,0.0002015228,0.005097318,0.0000161438],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958388,0.001393326,0.001504153,0.00006629099,0.0000207535,0.00000862979,0.00006407917,0.00002768413,0.00107638],"genre_scores_gemma":[0.9969792,0.0006869767,0.000940993,0.00004452417,0.00001285292,0.00000675009,0.0002165062,0.00001156079,0.001100608],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001638767,"threshold_uncertainty_score":0.005482256,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08376525856171736,"score_gpt":0.3304831668475252,"score_spread":0.2467179082858079,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}