{"id":"W2140479040","doi":"10.1371/journal.pgen.1001300","title":"Genome-Wide Association Study of Coronary Heart Disease and Its Risk Factors in 8,090 African Americans: The NHLBI CARe Project","year":2011,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":316,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"National Center for Research Resources; National Human Genome Research Institute; Pfizer; National Heart, Lung, and Blood Institute; National Institute on Aging; National Institutes of Health; Esperion Therapeutics; BG Medicine; AstraZeneca; National Cancer Institute; Cleveland Clinic; National Institute of Diabetes and Digestive and Kidney Diseases; Johns Hopkins University; Wake Forest University; Abbott Laboratories","keywords":"Genome-wide association study; Linkage disequilibrium; Biology; Single-nucleotide polymorphism; Genetics; Genetic association; Genetic genealogy; SNP; Allele; Population stratification; Population; Genotype; Medicine; Environmental health; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002137662,0.0001560252,0.000236115,0.00005300068,0.0000910923,0.000006072935,0.0001696827,0.0001008764,0.000006465586],"category_scores_gemma":[0.000612955,0.0001239649,0.00005102837,0.0001417952,0.00004686485,0.000002173473,0.0001328936,0.0001142196,0.000001426391],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004726307,"about_ca_system_score_gemma":0.0000929501,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002195873,"about_ca_topic_score_gemma":0.0003993203,"domain_scores_codex":[0.9985458,0.0004191586,0.0003183998,0.0003098764,0.0001485766,0.0002581516],"domain_scores_gemma":[0.99912,0.0001094077,0.0002723859,0.0002933719,0.0001370509,0.00006775846],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00003884813,0.0002692908,0.992878,0.00001084837,0.0001093343,7.199512e-7,0.004062163,0.0001190513,0.002398716,4.855392e-7,0.0000669678,0.00004563735],"study_design_scores_gemma":[0.0003451224,0.0007548249,0.9880399,0.00000332693,0.0001309673,1.893659e-7,0.008779962,0.00009690552,0.001413747,0.0000314519,0.0002654874,0.0001381904],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997102,0.001830757,0.000009293216,0.00005636586,0.00004147409,0.0007246049,0.00009510907,0.000006117208,0.0001342971],"genre_scores_gemma":[0.9988754,0.0006323397,0.0001611956,0.00009426856,0.00004090078,0.00007160536,0.00005151748,0.00001992996,0.00005288879],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004838113,"threshold_uncertainty_score":0.5055141,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0351016054282941,"score_gpt":0.2639814913651551,"score_spread":0.228879885936861,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}