{"id":"W2140511126","doi":"10.1158/0008-5472.can-06-4317","title":"Improvement of Antitumor Activity by Gene Amplification with a Replicating but Nondisseminating Adenovirus","year":2007,"lang":"en","type":"article","venue":"Cancer Research","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institut National de la Recherche Scientifique; Montreal Neurological Institute and Hospital; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Cytosine deaminase; Genetic enhancement; Suicide gene; In vivo; Bystander effect; Vector (molecular biology); Viral vector; Biology; Transgene; Cancer research; Virology; Molecular biology; Virus; Viral replication; Adenoviridae; Gene; Immunology; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002291212,0.0001255108,0.0001423096,0.0001210284,0.0001797855,0.00002701849,0.0003698941,0.00009252083,0.00003624388],"category_scores_gemma":[0.0001329256,0.0001135465,0.00003850024,0.000419256,0.0002485625,0.000006915998,0.0001490838,0.0002792499,0.000004413143],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001264213,"about_ca_system_score_gemma":0.000307141,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005079054,"about_ca_topic_score_gemma":0.0003182686,"domain_scores_codex":[0.9979457,0.00008518856,0.0002181332,0.0005291252,0.0006418526,0.0005800345],"domain_scores_gemma":[0.998485,0.00005785898,0.0001219317,0.0006798852,0.0005195918,0.0001357876],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002086149,0.000105374,0.001600406,0.00005404284,0.00004366535,0.000002537618,0.00005039477,0.000008591076,0.9327228,0.000005191226,0.0003366634,0.0629842],"study_design_scores_gemma":[0.0004613426,0.001847808,0.001021938,0.00003050268,0.000003807181,0.00000293745,0.0001468607,0.00001750965,0.9955282,0.000006677693,0.000806094,0.0001263564],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995684,0.001087529,0.002008806,0.0001393225,0.00001668526,0.0005363477,0.00005824565,0.000009820452,0.000459263],"genre_scores_gemma":[0.9982055,0.0002973407,0.0003121708,0.00003027286,0.0001370019,0.000176129,0.00004748955,0.0000381281,0.000755959],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06285784,"threshold_uncertainty_score":0.4630294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04093101733635616,"score_gpt":0.4064647640434927,"score_spread":0.3655337467071365,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}