{"id":"W2140528350","doi":"10.1172/jci29255","title":"Role for protease activity in visceral pain in irritable bowel syndrome","year":2007,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Gastrointestinal motility and disorders","field":"Medicine","cited_by":580,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Canadian Institutes of Health Research; National Institutes of Health; Fondation pour la Recherche Médicale; Alberta Heritage Foundation for Medical Research; Crohn's and Colitis Foundation of Canada; Canadian Association of Gastroenterology; Crohn's and Colitis Foundation","keywords":"Irritable bowel syndrome; Medicine; Proteases; Hyperalgesia; Visceral pain; Protease; Internal medicine; Protease-activated receptor 2; Tryptase; Sensitization; Allodynia; Gastroenterology; Endocrinology; Immunology; Nociception; Receptor; Mast cell; Chemistry; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002607472,0.0004907798,0.0003722899,0.0003768579,0.0001706627,0.0003883675,0.000120452,0.0003500246,0.001095225],"category_scores_gemma":[0.000567197,0.0001248099,0.0002073399,0.0001770413,0.0003451857,0.0002677469,0.0002752353,0.0004588165,0.0001970576],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001535189,"about_ca_system_score_gemma":0.0000809214,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001237717,"about_ca_topic_score_gemma":0.0001041828,"domain_scores_codex":[0.9998432,0.00006657335,0.00001693971,0.0000227639,0.00002962981,0.00002076231],"domain_scores_gemma":[0.9997743,0.00005782244,0.00009112931,0.00001459665,0.00002192295,0.00004024234],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006470356,0.0002385642,0.07082555,0.0008292563,0.0002129341,0.009393054,0.0002867763,0.0002228565,0.8712569,0.000481484,0.0004069085,0.03937531],"study_design_scores_gemma":[0.000287388,0.004169319,0.8458811,0.0001081255,0.0002749445,0.03240766,0.0003289896,0.001515968,0.1103207,0.0006902487,0.00398538,0.00003008009],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9759493,0.02147906,0.001168547,0.0003021218,0.00002936552,0.00001564764,0.00008125823,0.00003350956,0.0009413745],"genre_scores_gemma":[0.9971066,0.002088595,0.0005014361,0.00004293576,0.00003621537,0.000006312715,0.00005275429,0.000002312453,0.0001628002],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001095225,"threshold_uncertainty_score":0.003663898,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06498046728787583,"score_gpt":0.3771222736920648,"score_spread":0.312141806404189,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}