{"id":"W2140528350","doi":"10.1172/jci29255","title":"Role for protease activity in visceral pain in irritable bowel syndrome","year":2007,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Gastrointestinal motility and disorders","field":"Medicine","cited_by":580,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Canadian Institutes of Health Research; National Institutes of Health; Fondation pour la Recherche Médicale; Alberta Heritage Foundation for Medical Research; Crohn's and Colitis Foundation of Canada; Canadian Association of Gastroenterology; Crohn's and Colitis Foundation","keywords":"Irritable bowel syndrome; Medicine; Proteases; Hyperalgesia; Visceral pain; Protease; Internal medicine; Protease-activated receptor 2; Tryptase; Sensitization; Allodynia; Gastroenterology; Endocrinology; Immunology; Nociception; Receptor; Mast cell; Chemistry; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.01189736,0.00009074156,0.0004194636,0.0001983147,0.00002001071,0.00001156926,0.00006507055,0.0001266769,0.00001135075],"category_scores_gemma":[0.01475531,0.00007934689,0.0001663991,0.0002058813,0.0001048388,0.0002489048,0.0000110252,0.0006141432,0.000002095911],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007897212,"about_ca_system_score_gemma":0.0002886264,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009314117,"about_ca_topic_score_gemma":0.0002169543,"domain_scores_codex":[0.9978614,0.000222861,0.001318792,0.0001384331,0.0002357454,0.0002227907],"domain_scores_gemma":[0.9979833,0.0009639694,0.0005094213,0.00009361948,0.0001602914,0.0002894099],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002210645,0.0007720735,0.9765118,0.0001277725,0.00001129033,0.0001158768,0.00007874761,0.000118996,0.003215699,0.00005772767,0.0001500288,0.01662934],"study_design_scores_gemma":[0.003888354,0.002644322,0.9774746,0.0005421864,0.00002172018,0.0001231343,0.00014082,0.003677567,0.000447248,0.01084055,0.0001392476,0.00006020218],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919272,0.00003718401,0.003802219,0.003536475,0.00008788607,0.0004785389,0.000001107005,0.000006588507,0.0001227961],"genre_scores_gemma":[0.9841049,0.000003870775,0.01502518,0.0006746409,0.0001235418,0.000005718507,0.000002664012,0.000008841233,0.00005059865],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01656914,"threshold_uncertainty_score":0.9935438,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06498046728787583,"score_gpt":0.3771222736920648,"score_spread":0.312141806404189,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}