{"id":"W2140566427","doi":"10.1086/650464","title":"Effect of the Neuraminidase Mutation H274Y Conferring Resistance to Oseltamivir on the Replicative Capacity and Virulence of Old and Recent Human Influenza A(H1N1) Viruses","year":2010,"lang":"en","type":"article","venue":"The Journal of Infectious Diseases","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":137,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Canadian Institutes of Health Research","keywords":"Neuraminidase; Oseltamivir; Virology; Neuraminidase inhibitor; Virus; Biology; Virulence; Microbiology; Influenza A virus; Viral replication; Titer; Influenza A virus subtype H5N1; Mutant; Gene; Medicine; Genetics; Coronavirus disease 2019 (COVID-19); Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002360802,0.000309569,0.0001862313,0.000143881,0.0001405046,0.0002027303,0.0002438347,0.0003208056,0.0009778617],"category_scores_gemma":[0.0002706453,0.0001276865,0.0002119738,0.00007470405,0.0002291557,0.0001318093,0.0001139612,0.0003311552,0.0002137218],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002937355,"about_ca_system_score_gemma":0.0001850033,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002318139,"about_ca_topic_score_gemma":0.001882165,"domain_scores_codex":[0.9998628,0.00003935434,0.00001482814,0.00002282678,0.00002817341,0.00003212136],"domain_scores_gemma":[0.9997737,0.00009183427,0.0000376455,0.00001776791,0.00002170566,0.00005741994],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001152872,0.0002197492,0.001612472,0.00003614201,0.00002997321,0.0001216196,0.00004137987,0.0002267044,0.9948761,0.0000436505,0.0000729029,0.001566331],"study_design_scores_gemma":[0.0001549472,0.007401239,0.0280101,0.00001393629,0.00009952709,0.000682815,0.0001202612,0.002654709,0.959251,0.00003175485,0.00155993,0.00001985209],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995514,0.0001375213,0.00004750479,0.00001110678,0.000006132489,0.000005445944,0.00004135155,0.000003950546,0.0001956407],"genre_scores_gemma":[0.9992273,0.0001111741,0.0001675134,0.0000147159,0.000004182361,0.000005444215,0.0001181391,0.000003942443,0.0003475843],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002318139,"threshold_uncertainty_score":0.004609287,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04171937110741584,"score_gpt":0.3635976747180777,"score_spread":0.3218783036106618,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}