{"id":"W2140592061","doi":"10.1084/jem.20030976","title":"Fyn and PTP-PEST–mediated Regulation of Wiskott-Aldrich Syndrome Protein (WASp) Tyrosine Phosphorylation Is Required for Coupling T Cell Antigen Receptor Engagement to WASp Effector Function and T Cell Activation","year":2004,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":196,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network; Mount Sinai Hospital","funders":"","keywords":"Wiskott–Aldrich syndrome protein; Biology; FYN; Protein tyrosine phosphatase; Tyrosine phosphorylation; Cell biology; SH2 domain; Phosphorylation; Tyrosine; Proto-oncogene tyrosine-protein kinase Src; Receptor tyrosine kinase; Biochemistry; Actin cytoskeleton; Cytoskeleton; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001335596,0.0005087396,0.0002029005,0.0001615018,0.0001733077,0.0002394023,0.0001708063,0.0002870655,0.0007365854],"category_scores_gemma":[0.0001156418,0.0001618832,0.0002328426,0.00008736676,0.0003333697,0.0001834089,0.0002805858,0.0005134311,0.0002835201],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000383597,"about_ca_system_score_gemma":0.0002369256,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006198576,"about_ca_topic_score_gemma":0.001022956,"domain_scores_codex":[0.999842,0.00002954104,0.00002175328,0.00003415867,0.00003543525,0.0000370446],"domain_scores_gemma":[0.9998995,0.00001294081,0.0000404871,0.000007073149,0.000007217086,0.00003263363],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006423061,0.0000126619,0.000106956,0.00001682414,0.000002400904,0.00006714275,0.000006976128,0.00006670124,0.9991876,0.0000901647,0.00001566754,0.0003626745],"study_design_scores_gemma":[0.00002098259,0.0001487217,0.004558943,0.000005856527,0.000009557149,0.0003768354,0.00001994312,0.002176905,0.9914752,0.00005938418,0.001144155,0.000003492206],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970177,0.0006063843,0.001457848,0.00006258723,0.00001718435,0.00002159748,0.0001710897,0.00004662,0.0005990123],"genre_scores_gemma":[0.9968554,0.0003676644,0.001235527,0.00002801296,0.000005861894,0.00004383647,0.0002959729,0.00001169705,0.001156048],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007365854,"threshold_uncertainty_score":0.002783239,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02518495222550747,"score_gpt":0.296722738317703,"score_spread":0.2715377860921955,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}