{"id":"W2140592061","doi":"10.1084/jem.20030976","title":"Fyn and PTP-PEST–mediated Regulation of Wiskott-Aldrich Syndrome Protein (WASp) Tyrosine Phosphorylation Is Required for Coupling T Cell Antigen Receptor Engagement to WASp Effector Function and T Cell Activation","year":2004,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":196,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network; Mount Sinai Hospital","funders":"","keywords":"Wiskott–Aldrich syndrome protein; Biology; FYN; Protein tyrosine phosphatase; Tyrosine phosphorylation; Cell biology; SH2 domain; Phosphorylation; Tyrosine; Proto-oncogene tyrosine-protein kinase Src; Receptor tyrosine kinase; Biochemistry; Actin cytoskeleton; Cytoskeleton; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001445866,0.0002014678,0.0004370103,0.0002976058,0.0001456643,0.00001167898,0.00008755402,0.00009135486,0.0001405437],"category_scores_gemma":[0.0002542377,0.0001368074,0.00005174009,0.0003392287,0.0001353619,0.0001624923,0.00005496863,0.0002326699,0.00000497132],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002614877,"about_ca_system_score_gemma":0.00008108308,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005553399,"about_ca_topic_score_gemma":5.318884e-7,"domain_scores_codex":[0.9980689,0.00009450625,0.000663531,0.0002078587,0.0007492504,0.0002160014],"domain_scores_gemma":[0.998525,0.0002345945,0.0005011706,0.0001986125,0.0003221523,0.0002184401],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003833167,0.000270023,0.0003628195,0.0002147804,0.00004983189,0.000003087825,0.002059518,0.00009050016,0.9923195,0.00001071938,0.0003836311,0.0004023757],"study_design_scores_gemma":[0.007891974,0.009388486,0.01319531,0.000905398,0.0001136213,0.00004039943,0.00161749,0.0005676216,0.9659288,0.00004515737,0.0001927746,0.0001130002],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889014,0.002641712,0.003977038,0.002143277,0.0001498415,0.002132277,0.000004453754,0.00001254282,0.00003745496],"genre_scores_gemma":[0.9973609,0.0001891078,0.001833972,0.0001678343,0.0001801704,0.00003104758,0.00003554502,0.00003676399,0.0001646468],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02639078,"threshold_uncertainty_score":0.5578843,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02518495222550747,"score_gpt":0.296722738317703,"score_spread":0.2715377860921955,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}