{"id":"W2140609232","doi":"10.1016/s0140-6736(12)60681-3","title":"Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study","year":2012,"lang":"en","type":"article","venue":"The Lancet","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":423,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Institute of Genetics; University of Ioannina; Medical Research Council; Tufts University School of Medicine; Versus Arthritis; Háskólinn á Akureyri; Tartu Ülikool; Háskóli Íslands; Memorial University of Newfoundland; Institute of Molecular and Cell Biology; School of Medicine, Stanford University; Universiteit Leiden; Newcastle University; University of Oxford; Arthritis Research UK; University of Southampton; King's College London; National Institute for Health and Care Research; Wellcome Trust","keywords":"Genome-wide association study; Genetics; Genetic association; Linkage disequilibrium; SNP; Osteoarthritis; Candidate gene; Odds ratio; Single-nucleotide polymorphism; Medicine; Biology; Bioinformatics; Gene; Internal medicine; Genotype; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002853313,0.000894464,0.001012203,0.001458599,0.0007062033,0.001328297,0.001096688,0.001861293,0.003433129],"category_scores_gemma":[0.003958006,0.0006622766,0.002228135,0.002844485,0.0007189839,0.0004547121,0.0009295475,0.001773397,0.0004684307],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001954036,"about_ca_system_score_gemma":0.0004179131,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003319281,"about_ca_topic_score_gemma":0.004668396,"domain_scores_codex":[0.9982988,0.0005422194,0.0001949166,0.0004943942,0.0002762788,0.0001933364],"domain_scores_gemma":[0.9972219,0.001137122,0.000657057,0.0004078421,0.0002430629,0.0003329889],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.009901889,0.0004836039,0.9172917,0.0004689803,0.00939366,0.003070352,0.0003957599,0.0002775314,0.03447305,0.0005010308,0.001905246,0.0218373],"study_design_scores_gemma":[0.0006330299,0.0005753483,0.988991,0.00004227609,0.004869513,0.001940072,0.0001670663,0.0002404393,0.0007435988,0.0003572109,0.001410598,0.00002975223],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883353,0.00681344,0.001274634,0.00103524,0.0001080022,0.00002784642,0.001247175,0.00003698954,0.001121428],"genre_scores_gemma":[0.9930508,0.002276764,0.002055041,0.0003912596,0.0002254477,0.00002338144,0.001130645,0.0000242119,0.0008224718],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003433129,"threshold_uncertainty_score":0.01508999,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03426620537248958,"score_gpt":0.2980940280649803,"score_spread":0.2638278226924907,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}