{"id":"W2140637559","doi":"10.1038/nm.3806","title":"A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases","year":2015,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2784,"is_retracted":false,"has_abstract":false,"ca_institutions":"Trinity College","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; National Institutes of Health","keywords":"Inflammasome; Pyrin domain; Experimental autoimmune encephalomyelitis; NALP3; Medicine; AIM2; Immunology; Nod; In vivo; NLRC4; Receptor; Inflammation; Caspase 1; Biology; Diabetes mellitus; Internal medicine; Endocrinology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003046426,0.0003776719,0.0005162531,0.000429145,0.0002881943,0.000400834,0.0004040968,0.0005907791,0.003823289],"category_scores_gemma":[0.0001267581,0.0001569126,0.0004944415,0.0003403708,0.0002430474,0.0003977938,0.0002703533,0.001385363,0.00100032],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002606738,"about_ca_system_score_gemma":0.0004095669,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004099868,"about_ca_topic_score_gemma":0.001063947,"domain_scores_codex":[0.99991,0.00001590488,0.000008103043,0.00001553423,0.00002950737,0.00002084867],"domain_scores_gemma":[0.9999608,0.000006253963,0.000007631928,0.000003161324,0.000006835829,0.00001540372],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003952722,0.0008649021,0.0002942064,0.001467946,0.0001695891,0.000935225,0.00007265,0.0007496599,0.773739,0.003583831,0.01359534,0.2005749],"study_design_scores_gemma":[0.008788506,0.01380184,0.007624787,0.0003951451,0.0005273835,0.005465819,0.00009730409,0.00283849,0.6566963,0.002780818,0.3008283,0.0001552646],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.3666416,0.5504608,0.03478969,0.009253988,0.0048951,0.001170746,0.002971289,0.001634063,0.02818275],"genre_scores_gemma":[0.7220564,0.2308767,0.01921996,0.002638846,0.0006397269,0.0004670047,0.00182789,0.00008216743,0.02219123],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.003823289,"threshold_uncertainty_score":0.01279014,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01149896473672759,"score_gpt":0.2514125145929787,"score_spread":0.2399135498562511,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}