{"id":"W2140639765","doi":"10.1161/01.res.0000143899.73453.11","title":"Tumor Necrosis Factor-α–Converting Enzyme (ADAM17) Mediates GPIbα Shedding From Platelets In Vitro and In Vivo","year":2004,"lang":"en","type":"article","venue":"Circulation Research","topic":"Platelet Disorders and Treatments","field":"Medicine","cited_by":224,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's Health Research Institute","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health","keywords":"Platelet; Platelet Glycoprotein GPIb-IX Complex; Von Willebrand factor; In vivo; Metalloproteinase; Tumor necrosis factor alpha; Chemistry; Glycoprotein Ib; Molecular biology; Platelet activation; Ex vivo; Immunology; Cell biology; Biology; Enzyme; In vitro; Cancer research; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000364567,0.0001376672,0.000319492,0.0004935669,0.0000990687,0.00005519317,0.00006614687,0.0001076903,0.0001543772],"category_scores_gemma":[0.0003500666,0.0001300209,0.00003709207,0.0005180403,0.00007460285,0.0002095859,0.00005492929,0.0003718689,0.00002957191],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003455379,"about_ca_system_score_gemma":0.0001288988,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004621028,"about_ca_topic_score_gemma":0.0005722467,"domain_scores_codex":[0.9982565,0.00007826533,0.0003187296,0.0003889475,0.0004865985,0.0004709614],"domain_scores_gemma":[0.9992749,0.0002845862,0.00004391502,0.0001728969,0.00007116138,0.0001525281],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003595772,0.0002907176,0.5955721,0.0000692875,0.00004912681,0.001407506,0.002259411,0.0004207057,0.3946898,0.00002571502,0.00001558161,0.004840413],"study_design_scores_gemma":[0.006303814,0.00005301154,0.8887633,0.0002530817,0.000009374005,0.00002972311,0.0004688655,0.005619261,0.09604454,0.002261711,0.00003118421,0.0001621459],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979671,0.0005404082,0.00001525039,0.0006261134,0.0000382333,0.0004752357,0.00002153717,0.00002731606,0.0002887996],"genre_scores_gemma":[0.9995224,0.00007830482,0.0001388889,0.0000810447,0.00003695596,0.00003745916,0.00006047907,0.00002294282,0.00002152827],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2986453,"threshold_uncertainty_score":0.6985642,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04844389781034574,"score_gpt":0.3404443798603859,"score_spread":0.2920004820500401,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}