{"id":"W2140639765","doi":"10.1161/01.res.0000143899.73453.11","title":"Tumor Necrosis Factor-α–Converting Enzyme (ADAM17) Mediates GPIbα Shedding From Platelets In Vitro and In Vivo","year":2004,"lang":"en","type":"article","venue":"Circulation Research","topic":"Platelet Disorders and Treatments","field":"Medicine","cited_by":224,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's Health Research Institute","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health","keywords":"Platelet; Platelet Glycoprotein GPIb-IX Complex; Von Willebrand factor; In vivo; Metalloproteinase; Tumor necrosis factor alpha; Chemistry; Glycoprotein Ib; Molecular biology; Platelet activation; Ex vivo; Immunology; Cell biology; Biology; Enzyme; In vitro; Cancer research; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000302181,0.0003580872,0.0002455616,0.0002101432,0.0001316973,0.0004906567,0.0001739286,0.0002317047,0.001029559],"category_scores_gemma":[0.0002466758,0.0002183757,0.0002644616,0.0001359297,0.000216289,0.0002083452,0.0001849171,0.0006774608,0.0006097738],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002468141,"about_ca_system_score_gemma":0.0001439821,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003849093,"about_ca_topic_score_gemma":0.0002696714,"domain_scores_codex":[0.9997504,0.00006612232,0.00002615462,0.00003430571,0.00006481594,0.00005814371],"domain_scores_gemma":[0.9998538,0.0000287436,0.0000400631,0.00003601953,0.00001256682,0.00002880784],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002899578,0.00005754779,0.0001921059,0.00002612955,0.000009922823,0.00007173038,0.00001761201,0.0000482018,0.9979963,0.00006654816,0.00005204506,0.001172013],"study_design_scores_gemma":[0.0000518571,0.0003658395,0.003981671,0.000004978683,0.00001656966,0.0006756041,0.00001867189,0.001170392,0.9918841,0.00005706442,0.001770395,0.000002802628],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927631,0.002678634,0.003205071,0.00013499,0.00003017102,0.00002942156,0.0002382714,0.00005621041,0.0008641354],"genre_scores_gemma":[0.9942484,0.001530347,0.001227407,0.00004311646,0.00001864727,0.00003563432,0.0007392456,0.00001807953,0.00213917],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001029559,"threshold_uncertainty_score":0.003444195,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04844389781034574,"score_gpt":0.3404443798603859,"score_spread":0.2920004820500401,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}