{"id":"W2140644802","doi":"10.1016/s0264-410x(03)00045-8","title":"A phase I study of the safety and immunogenicity of recombinant hepatitis B surface antigen co-administered with an immunostimulatory phosphorothioate oligonucleotide adjuvant","year":2003,"lang":"en","type":"article","venue":"Vaccine","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":260,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University; Izaak Walton Killam Health Centre","funders":"Clinical Trial Center, China Medical University Hospital","keywords":"HBsAg; Medicine; Immunogenicity; Adjuvant; Antigen; Immunology; Antibody; Antibody titer; Titer; Gastroenterology; Internal medicine; Pharmacology; Hepatitis B virus; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002375967,0.002548632,0.002197938,0.000868931,0.0007792925,0.001099974,0.001359258,0.002553832,0.002054842],"category_scores_gemma":[0.001395047,0.001099155,0.001500027,0.0006918837,0.002053661,0.001352958,0.0003210724,0.004097362,0.0006344725],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001053192,"about_ca_system_score_gemma":0.002124515,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001428196,"about_ca_topic_score_gemma":0.001269271,"domain_scores_codex":[0.9990063,0.0004602937,0.00003748335,0.0001721472,0.0000906232,0.0002331029],"domain_scores_gemma":[0.9984041,0.0003584319,0.0003256846,0.0002399495,0.000110747,0.000561202],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5209977,0.1953246,0.002111289,0.0006060418,0.0008414532,0.0004465156,0.0004967922,0.002069481,0.2428382,0.0006179549,0.001770395,0.03187967],"study_design_scores_gemma":[0.129648,0.8438021,0.001465649,0.00001320199,0.0002813765,0.0002123093,0.00005258949,0.0004552658,0.0230701,0.0001345433,0.0008447738,0.0000199989],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963396,0.0007162736,0.000772209,0.0002013986,0.0001354223,0.000964245,0.0002625874,0.0000566262,0.0005518034],"genre_scores_gemma":[0.992116,0.001059346,0.001491512,0.0003319939,0.0002953068,0.00157158,0.0008059213,0.00004103992,0.002287293],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002553832,"threshold_uncertainty_score":0.01256543,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01826303032470135,"score_gpt":0.2906095156763407,"score_spread":0.2723464853516394,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}