{"id":"W2140663833","doi":"10.1124/mol.114.093294","title":"Complex Pharmacology of Novel Allosteric Free Fatty Acid 3 Receptor Ligands","year":2014,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":68,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Canadian Institutes of Health Research","keywords":"Allosteric regulation; Chemistry; Biochemistry; Pharmacology; Receptor; Stereochemistry; Computational biology; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003970183,0.0002819478,0.0004225842,0.0001924777,0.0001780175,0.000543579,0.0004286769,0.0003378258,0.00238048],"category_scores_gemma":[0.0003579746,0.0001999582,0.0001889475,0.0001493934,0.0003328054,0.0003807554,0.0003547244,0.0008223421,0.0003073918],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005044335,"about_ca_system_score_gemma":0.0002211693,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003383828,"about_ca_topic_score_gemma":0.0009092747,"domain_scores_codex":[0.9998401,0.00004397989,0.00001048818,0.00002108026,0.00004057657,0.00004370848],"domain_scores_gemma":[0.9998829,0.00004145606,0.00002112896,0.00001877241,0.00001148542,0.00002424239],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001434931,0.0001297058,0.0004412479,0.00008464867,0.00002796674,0.0002752091,0.00008998885,0.001275311,0.9772075,0.007836746,0.0003257544,0.01087096],"study_design_scores_gemma":[0.0004939478,0.002047448,0.005704748,0.000028547,0.000113984,0.00223,0.0001612548,0.01435074,0.9542415,0.007549981,0.01300436,0.00007356821],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9760848,0.00300642,0.01541582,0.0006168982,0.00008092404,0.00007286112,0.0001451945,0.000159861,0.004417319],"genre_scores_gemma":[0.9914471,0.001533068,0.003762017,0.0002310104,0.00003803387,0.00004550426,0.0001528641,0.00002059234,0.002769829],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00238048,"threshold_uncertainty_score":0.007963538,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01782275622621473,"score_gpt":0.2807837400377126,"score_spread":0.2629609838114979,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}