{"id":"W2140688181","doi":"10.1002/anie.200390347","title":"Macrocyclic Inhibitors of the NS3 Protease as Potential Therapeutic Agents of Hepatitis C Virus Infection","year":2003,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Hepatitis C virus research","field":"Medicine","cited_by":188,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"NS3; Protease; Hepatitis C virus; Replicon; Virology; NS2-3 protease; Enzyme; Virus; Viral replication; Hepatitis C; Chemistry; RNA; Hepacivirus; Hepatitis virus; Biochemistry; Biology; DNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002094453,0.0001135338,0.0001618977,0.0001424255,0.00005302423,0.00001280634,0.000106266,0.0001098725,0.001239523],"category_scores_gemma":[0.0004864639,0.00009154626,0.0001664471,0.0002235166,0.0001341113,0.000154262,0.00003959934,0.0002097804,0.00003048421],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001747901,"about_ca_system_score_gemma":0.0001451735,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002213939,"about_ca_topic_score_gemma":0.0001161506,"domain_scores_codex":[0.9984333,0.00006889184,0.0003468795,0.000177972,0.0008231162,0.0001498306],"domain_scores_gemma":[0.9990654,0.0000340141,0.0002100095,0.0001981609,0.0004217471,0.00007064876],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001612946,0.0004520521,0.1549788,0.0001149035,0.0002087324,0.00001502573,0.0001605831,0.00001718769,0.8361341,0.0003384556,0.003828069,0.003590902],"study_design_scores_gemma":[0.0008384748,0.0001086123,0.0604612,0.000142201,0.00004525347,0.00002878676,0.00001033611,0.00005535328,0.9288698,0.0007449761,0.008626238,0.00006877482],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9831883,0.00007138714,0.0006682918,0.0004953084,0.001141924,0.000533831,0.00008581067,0.00002195898,0.01379321],"genre_scores_gemma":[0.9980891,0.0004967271,0.00004973938,0.0002105215,0.0004047924,0.00006808474,0.00010083,0.00001835987,0.0005618631],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09451755,"threshold_uncertainty_score":0.9996735,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02153756608588547,"score_gpt":0.3112899864348105,"score_spread":0.289752420348925,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}