{"id":"W2140727839","doi":"10.1093/hmg/ddu543","title":"LRRK2 overexpression alters glutamatergic presynaptic plasticity, striatal dopamine tone, postsynaptic signal transduction, motor activity and memory","year":2014,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Michael J. Fox Foundation for Parkinson's Research","keywords":"Biology; Neuroscience; Dopamine; Neurotransmission; Synaptic plasticity; Glutamatergic; Medium spiny neuron; Postsynaptic potential; Glutamate receptor; LRRK2; Dopamine receptor D2; Striatum; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0000851201,0.0003188981,0.0003579189,0.0001297623,0.0001697487,0.00004841381,0.00009724643,0.0001337324,0.0001919766],"category_scores_gemma":[0.00002284768,0.0002951071,0.0001181936,0.00007223037,0.0001094435,0.00005929069,0.00007739002,0.0001526882,0.00001649357],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006455718,"about_ca_system_score_gemma":0.0000428542,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002620516,"about_ca_topic_score_gemma":0.000003912229,"domain_scores_codex":[0.9983517,0.0001194561,0.0002389165,0.0005322404,0.0003994117,0.0003582556],"domain_scores_gemma":[0.9991162,0.00003309054,0.000101246,0.0003266424,0.00006198049,0.000360882],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003285382,0.0003830844,0.0005324029,0.0001369724,0.0002117018,0.00009993681,0.00006061371,0.0001500768,0.9957432,0.0001049827,0.00001338066,0.00223517],"study_design_scores_gemma":[0.008053629,0.003416594,0.2224659,0.000306705,0.001183562,0.0001995963,0.0000397675,0.01334497,0.7490166,0.001108729,0.0002331896,0.0006308008],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991657,0.0003193724,0.007075659,0.00005184847,0.00008099312,0.0005401008,0.00004360254,0.00007392163,0.0001575136],"genre_scores_gemma":[0.9984347,0.00004028364,0.001032032,0.000100975,0.0001154204,0.00003269157,0.00005476992,0.00005606609,0.0001330336],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2467266,"threshold_uncertainty_score":0.9999501,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01116429806194538,"score_gpt":0.2583541896322529,"score_spread":0.2471898915703075,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}