{"id":"W2140790130","doi":"10.3899/jrheum.120573","title":"Multiple Courses of Rituximab Produce Sustained Clinical and Radiographic Efficacy and Safety in Patients with Rheumatoid Arthritis and an Inadequate Response to 1 or More Tumor Necrosis Factor Inhibitors: 5-Year Data from the REFLEX Study","year":2012,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Mount Sinai Hospital","funders":"Versus Arthritis; National Institute for Health and Care Research; Genentech; AstraZeneca; Amgen; Pfizer; F. Hoffmann-La Roche","keywords":"Medicine; Randomized controlled trial; Rheumatoid arthritis; Internal medicine; Rituximab; Adverse effect; Randomization; Rheumatism; Placebo; Rheumatology; Gastroenterology; Surgery; Pathology; Lymphoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00988188,0.0004062949,0.001094369,0.0003330637,0.000328631,0.0005805112,0.0004356131,0.0006174101,0.001226572],"category_scores_gemma":[0.005775433,0.0002663537,0.001936896,0.000364778,0.0004825976,0.0007303001,0.0004989274,0.001062591,0.0003328466],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004462462,"about_ca_system_score_gemma":0.000790654,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006179179,"about_ca_topic_score_gemma":0.0009102915,"domain_scores_codex":[0.9961178,0.002103161,0.0005251582,0.0003911098,0.0005744259,0.0002882953],"domain_scores_gemma":[0.9883459,0.002688731,0.006014668,0.001285404,0.0007871206,0.0008780412],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.5418214,0.02057419,0.3259577,0.0007991796,0.006992721,0.0003032047,0.0004676145,0.00121857,0.01121542,0.0001287188,0.001592495,0.08892875],"study_design_scores_gemma":[0.05034287,0.342957,0.5943184,0.0001006373,0.003662483,0.0006583058,0.0002076734,0.001559119,0.003829174,0.0001182277,0.002169465,0.00007656201],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981518,0.0009248692,0.0002256255,0.00004315109,0.00001195921,0.0000946735,0.0002762651,0.00001048338,0.0002610954],"genre_scores_gemma":[0.9986853,0.0002116948,0.0002099336,0.00007327113,0.00003943776,0.0000567527,0.0005688223,0.000002308455,0.0001525269],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00988188,"threshold_uncertainty_score":0.05226099,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03505806304686895,"score_gpt":0.3408523862359314,"score_spread":0.3057943231890625,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}