{"id":"W2140793516","doi":"10.1158/1078-0432.ccr-04-2517","title":"Anti-CD19-Targeted Liposomal Doxorubicin Improves the Therapeutic Efficacy in Murine B-Cell Lymphoma and Ameliorates the Toxicity of Liposomes with Varying Drug Release Rates","year":2005,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":147,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Liposome; Pharmacology; Doxorubicin; Pharmacokinetics; Toxicity; Drug; Chemistry; Therapeutic index; Biodistribution; In vivo; Drug carrier; Phosphatidylcholine; Medicine; Biology; In vitro; Biochemistry; Chemotherapy; Internal medicine; Phospholipid; Membrane","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005033128,0.0002335033,0.0004905143,0.0001323126,0.0003423908,0.0001718237,0.0008243024,0.00009828746,0.0001168873],"category_scores_gemma":[0.000570351,0.0001207312,0.00008376403,0.0009340168,0.001895843,0.0002796732,0.0003732781,0.0005613291,0.00004247427],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001011291,"about_ca_system_score_gemma":0.0005614638,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001433207,"about_ca_topic_score_gemma":0.0006065299,"domain_scores_codex":[0.9952935,0.001646527,0.0008290578,0.0006410272,0.0008143405,0.000775543],"domain_scores_gemma":[0.9931389,0.005372426,0.0002195818,0.000744366,0.000341135,0.0001836078],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001549686,0.001360578,0.01659334,0.00007417474,0.00002675459,0.00001735015,0.0008255927,0.0007002383,0.9668908,0.00003895676,0.0002339218,0.01168863],"study_design_scores_gemma":[0.003700155,0.0004491138,0.05901536,0.0001218059,0.00002944095,0.000003253146,0.0003650342,0.002198742,0.9336291,0.00009576864,0.0002113382,0.0001809188],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987222,0.005289308,0.000002148634,0.006432108,0.0001121373,0.000841927,0.00001914205,0.0000398051,0.00004144078],"genre_scores_gemma":[0.9976799,0.001160119,0.0001185233,0.0005045192,0.0002928105,0.00007386987,0.000001670047,0.00003590489,0.0001326979],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04242202,"threshold_uncertainty_score":0.6985313,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05686369356701386,"score_gpt":0.3860456470176086,"score_spread":0.3291819534505947,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}