{"id":"W2140804609","doi":"10.1139/o08-034","title":"eIF4E, the mRNA cap-binding protein: from basic discovery to translational researchThis paper is one of a selection of papers published in this Special Issue, entitled CSBMCB — Systems and Chemical Biology, and has undergone the Journal's usual peer review process.","year":2008,"lang":"en","type":"review","venue":"Biochemistry and Cell Biology","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":186,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Canadian Institutes of Health Research","keywords":"EIF4E; Biology; Ribosome biogenesis; RNA splicing; Translation (biology); Computational biology; Biogenesis; Cell biology; Messenger RNA; Eukaryotic translation; Genetics; Eukaryotic initiation factor; Alternative splicing; Initiation factor; Eukaryotic translation initiation factor 4 gamma; Translational regulation; Precursor mRNA; Translational efficiency; Gene; Ribosome; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0009074616,0.000352203,0.0009079704,0.00006630277,0.0001389388,0.00005065856,0.0003677647,0.000692413,0.0009628464],"category_scores_gemma":[0.0003959832,0.0002249205,0.000151929,0.0002620453,0.0007204522,0.00001496384,0.0001453998,0.0005546886,9.77315e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003948419,"about_ca_system_score_gemma":0.0005598164,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001178082,"about_ca_topic_score_gemma":0.00001411896,"domain_scores_codex":[0.9977196,0.0003688953,0.0007557837,0.0006003129,0.0002530924,0.0003022583],"domain_scores_gemma":[0.9986889,0.0001697552,0.000494288,0.000298413,0.0002502511,0.00009834571],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002511164,0.0001192348,0.0002097637,0.01021421,0.0004524171,0.000001897334,0.0001808811,4.831373e-7,0.9542402,0.00001141557,0.01197159,0.02234676],"study_design_scores_gemma":[0.0006199135,0.000234154,0.000008422036,0.004556818,0.0002747736,0.0001093997,0.00007664225,0.000002042064,0.2068036,0.00003911754,0.786921,0.0003541824],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.03757593,0.9595681,0.000007659896,0.0007806724,0.0001206673,0.0008090334,0.0003832852,0.000003284618,0.0007513838],"genre_scores_gemma":[0.0230104,0.9737694,0.00003841042,0.00009014746,0.001203395,0.0001032434,0.0004938561,0.00002763662,0.00126354],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7749494,"threshold_uncertainty_score":0.9999504,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03419759186651217,"score_gpt":0.3094796197980501,"score_spread":0.2752820279315379,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}