{"id":"W2140804609","doi":"10.1139/o08-034","title":"eIF4E, the mRNA cap-binding protein: from basic discovery to translational researchThis paper is one of a selection of papers published in this Special Issue, entitled CSBMCB — Systems and Chemical Biology, and has undergone the Journal's usual peer review process.","year":2008,"lang":"en","type":"review","venue":"Biochemistry and Cell Biology","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":186,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Canadian Institutes of Health Research","keywords":"EIF4E; Biology; Ribosome biogenesis; RNA splicing; Translation (biology); Computational biology; Biogenesis; Cell biology; Messenger RNA; Eukaryotic translation; Genetics; Eukaryotic initiation factor; Alternative splicing; Initiation factor; Eukaryotic translation initiation factor 4 gamma; Translational regulation; Precursor mRNA; Translational efficiency; Gene; Ribosome; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008176573,0.0009520774,0.001217118,0.002152876,0.0003345081,0.001172333,0.0009539097,0.001497847,0.002283866],"category_scores_gemma":[0.0006060795,0.0003830157,0.0003587948,0.002843278,0.001013438,0.002234046,0.0007234845,0.002780695,0.003357556],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001233883,"about_ca_system_score_gemma":0.001132383,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006263061,"about_ca_topic_score_gemma":0.001148878,"domain_scores_codex":[0.9998204,0.00002410571,0.00002525324,0.0000347586,0.00007598299,0.00001949067],"domain_scores_gemma":[0.9997112,0.0000925936,0.00004067044,0.00001305353,0.00008227681,0.00006021975],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001092018,0.00007788572,0.0001591939,0.006971412,0.0000498518,0.0002573618,0.00005650798,0.0003480856,0.004881212,0.006170044,0.05298518,0.9279341],"study_design_scores_gemma":[0.00002020758,0.00006063832,0.0003928681,0.0006575877,0.00002838244,0.0008914594,0.00003288313,0.00006915609,0.0009162668,0.00218312,0.9947345,0.00001293412],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001304025,0.9968891,0.0002747015,0.0007831833,0.000773209,0.000005652431,0.00001336141,0.00001317593,0.001117201],"genre_scores_gemma":[0.0005826194,0.9972802,0.0003276739,0.0003629599,0.0004228313,0.000005656677,0.00002727821,0.000002035159,0.0009886575],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002283866,"threshold_uncertainty_score":0.008952439,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03419759186651217,"score_gpt":0.3094796197980501,"score_spread":0.2752820279315379,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}