{"id":"W2140808124","doi":"10.1073/pnas.1105062108","title":"AMP-activated protein kinase (AMPK) β1β2 muscle null mice reveal an essential role for AMPK in maintaining mitochondrial content and glucose uptake during exercise","year":2011,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":402,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Medical Research Council; Canadian Institutes of Health Research; University of Melbourne; H. Lundbeck A/S; National Health and Medical Research Council; McMaster University; State Government of Victoria; Sundhed og Sygdom, Det Frie Forskningsråd","keywords":"AMPK; AMP-activated protein kinase; Protein kinase A; Null (SQL); Chemistry; Internal medicine; Cell biology; Endocrinology; Mitochondrion; Kinase; Biochemistry; Biology; Medicine; Computer science; Data mining","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005241766,0.0001070161,0.0001576105,0.00008076971,0.0001219477,0.00001999778,0.000369923,0.0001067927,0.000006420291],"category_scores_gemma":[0.0002198075,0.00008429886,0.00005600074,0.0001722852,0.0003330012,0.00005410002,0.0001050277,0.0000876093,1.274822e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001280413,"about_ca_system_score_gemma":0.00003545699,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003110311,"about_ca_topic_score_gemma":0.00000211041,"domain_scores_codex":[0.998887,0.000009100172,0.0002771921,0.0003201079,0.0003094097,0.0001971623],"domain_scores_gemma":[0.9994732,0.000008481486,0.0002658455,0.00001486635,0.0001857547,0.00005186442],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000249839,0.00005691293,0.0004801461,0.00004820069,0.00000815898,6.310398e-9,0.0002952069,0.000005431372,0.9960191,0.0007045955,0.00001740886,0.002114944],"study_design_scores_gemma":[0.000713454,0.00006787623,0.02713614,0.00009123656,0.00001115932,0.000001139465,0.0003313347,0.00004826245,0.9678836,0.003084565,0.0005273662,0.0001037934],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965437,0.002754035,0.000002184502,0.00004737601,0.00003139808,0.0004573932,0.00002411238,0.000004106909,0.000135672],"genre_scores_gemma":[0.9964311,0.0002705652,0.002944212,0.00005312792,0.0001595152,0.00008223948,0.000001387917,0.000007176308,0.00005070924],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02813548,"threshold_uncertainty_score":0.3437608,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04158546927396539,"score_gpt":0.2769103155685294,"score_spread":0.235324846294564,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}