{"id":"W2140810234","doi":"10.3389/fmicb.2010.00129","title":"Francisella Tularensis Blue–Gray Phase Variation Involves Structural Modifications of Lipopolysaccharide O-Antigen, Core and Lipid A and Affects Intramacrophage Survival and Vaccine Efficacy","year":2010,"lang":"en","type":"article","venue":"Frontiers in Microbiology","topic":"Bacillus and Francisella bacterial research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; China Scholarship Council; U.S. Department of Energy","keywords":"Francisella tularensis; Microbiology; Biology; Phase variation; Lipopolysaccharide; Lipid A; Francisella; Antigen; Virulence; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009470036,0.0002854964,0.0001557137,0.0002057503,0.0000934699,0.0002073911,0.0001451568,0.000296539,0.0009158564],"category_scores_gemma":[0.0001701483,0.0000966861,0.0002406938,0.0001124887,0.0002135933,0.0002059669,0.0002054202,0.0003354037,0.0001616996],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002218606,"about_ca_system_score_gemma":0.0001178684,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001071647,"about_ca_topic_score_gemma":0.000954784,"domain_scores_codex":[0.9998877,0.00001648411,0.000009744433,0.00002337403,0.00002804022,0.00003465151],"domain_scores_gemma":[0.9998661,0.00001998527,0.00005854741,0.00001131469,0.00001746334,0.00002646459],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000732569,0.00001843839,0.0005870291,0.000008083162,0.000003273901,0.00003778037,0.0000119084,0.00001365302,0.9984713,0.00003213177,0.00001776575,0.0007254012],"study_design_scores_gemma":[0.00001960194,0.0009216837,0.04423223,0.000009747313,0.00002986945,0.000854853,0.0001409462,0.0004998266,0.9516639,0.0001876037,0.00142567,0.00001402684],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998594,0.0001843063,0.0006952111,0.00004212747,0.000006639579,0.000007010266,0.00009455821,0.00001982205,0.0003563412],"genre_scores_gemma":[0.9984972,0.00008872952,0.0005549066,0.00005842267,0.000003847359,0.000006977945,0.0001962726,0.00001116767,0.0005824151],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001071647,"threshold_uncertainty_score":0.003063858,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008701893535074287,"score_gpt":0.2610821572142783,"score_spread":0.252380263679204,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}