{"id":"W2140828248","doi":"10.1093/hmg/ddn188","title":"Polygenic determinants of severe hypertriglyceridemia","year":2008,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Lipid metabolism and disorders","field":"Medicine","cited_by":129,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hamilton Health Sciences; McMaster University; Population Health Research Institute; Western University; Robarts Clinical Trials","funders":"World Health Organization","keywords":"Biology; Hypertriglyceridemia; Single-nucleotide polymorphism; Genome-wide association study; Genetics; Quantitative trait locus; Allele; Genotype; Internal medicine; Genetic association; Genetic variation; Endocrinology; Gene; Triglyceride; Cholesterol; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003307169,0.0003098421,0.0002652042,0.0004955612,0.0002812218,0.000317382,0.0001517628,0.0003055601,0.001382137],"category_scores_gemma":[0.001087132,0.0001537398,0.0003614586,0.0005523802,0.0003280969,0.0001238968,0.0003885223,0.0002800558,0.0001177565],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000972457,"about_ca_system_score_gemma":0.0001473205,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00167412,"about_ca_topic_score_gemma":0.002166823,"domain_scores_codex":[0.999687,0.0001305053,0.00003456842,0.00008119525,0.00003136236,0.00003544831],"domain_scores_gemma":[0.9994012,0.0001529835,0.0002050217,0.00008332838,0.00002547993,0.0001318906],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004774862,0.00003012493,0.9856696,0.00001644792,0.0002362582,0.001018341,0.0001379249,0.0003048595,0.008681563,0.0002107172,0.00008485437,0.003131853],"study_design_scores_gemma":[0.000008688926,0.00007232404,0.9977655,0.000002381091,0.00004073601,0.001130951,0.00004716257,0.0004500754,0.0002096023,0.0001951567,0.00007281882,0.000004487031],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993746,0.00007057738,0.0002350305,0.00002594192,0.000001629725,0.000003629056,0.00007786432,0.000004156065,0.0002065891],"genre_scores_gemma":[0.9997191,0.00002309337,0.0001036559,0.000008396207,0.000003936972,0.000001681414,0.00007690855,0.000001180099,0.00006213674],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00167412,"threshold_uncertainty_score":0.004623711,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02541703553730019,"score_gpt":0.2838298755765364,"score_spread":0.2584128400392363,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}