{"id":"W2140832617","doi":"10.1200/jco.2014.57.3055","title":"Molecular Testing for Selection of Patients With Lung Cancer for Epidermal Growth Factor Receptor and Anaplastic Lymphoma Kinase Tyrosine Kinase Inhibitors: American Society of Clinical Oncology Endorsement of the College of American Pathologists/International Association for the Study of Lung Cancer/Association for Molecular Pathology Guideline","year":2014,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":290,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"International Association for the Study of Lung Cancer","keywords":"Medicine; Guideline; Anaplastic lymphoma kinase; Lung cancer; Oncology; Epidermal growth factor receptor; Internal medicine; Cancer; Family medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.003315947,0.000182586,0.001836507,0.00009267782,0.00007726572,0.000002611059,0.000163012,0.0002162345,0.000003368333],"category_scores_gemma":[0.01525983,0.0001138831,0.0005955059,0.0002706435,0.000328162,0.00005789033,0.00004755449,0.0001885964,6.362859e-9],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009090728,"about_ca_system_score_gemma":0.001756269,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004211407,"about_ca_topic_score_gemma":0.0003408903,"domain_scores_codex":[0.9950892,0.0005509775,0.00338401,0.0002784483,0.000458265,0.0002390447],"domain_scores_gemma":[0.9722559,0.01003107,0.01219502,0.0001364843,0.005288399,0.00009308549],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007805192,0.004551996,0.9325947,0.0002529024,0.003116772,0.000001048515,0.0003110383,0.0008099474,0.004002444,0.00005870273,0.00166138,0.04483386],"study_design_scores_gemma":[0.04510512,0.07324171,0.8509957,0.0002509837,0.006529385,0.000003527189,0.0009285247,0.01545869,0.005297234,0.00006292257,0.001962208,0.0001640441],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9809075,0.0001282622,0.0105758,0.003481837,0.0008355698,0.002799287,0.001262083,0.000003706774,0.000005953695],"genre_scores_gemma":[0.9811685,0.0001194646,0.0174979,0.0004152975,0.0003750844,0.0003461761,0.00003521311,0.00002582218,0.00001655228],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08159907,"threshold_uncertainty_score":0.9930351,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03833756373049924,"score_gpt":0.4406086431182212,"score_spread":0.4022710793877219,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}